{"doi":"10.7889/tct-23-033","title":"Diagnosis, evaluation and management for oral chronic GVHD","abstract":"口腔は，同種造血幹細胞移植後の慢性移植片対宿主病（chrnonic graft versus host disease，cGVHD）における代表的な標的臓器の一つである。症状としては，口腔粘膜の扁平苔癬様変化，疼痛，口腔乾燥そして味覚障害等が特徴的であり，口腔の健康状態の悪化，口腔機能の低下，ひいては経口摂取に支障を来すことで，生活の質の低下をもたらす。本稿では，慢性GVHDの口腔症状に関する診断，評価およびマネジメントについて概説した。診断および評価は，日本造血・免疫細胞療法学会のガイドラインに従い，NIH consensus development projectが提唱している基準によって行う。症状マネジメントにあたっては，口腔カンジダ症や口腔乾燥症といった増悪因子を取り除き，口腔衛生管理を徹底する必要がある。GVL効果を減弱させないよう，口腔用のステロイド製剤の局所投与で対応することが望ましい。","journal":"Japanese Journal of Transplantation and Cellular Therapy","year":2024,"id":496612,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":0.0,"corpus_rank":10062,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":true,"is_dataset_confidence":0.7848,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1227331,"name":"Yoshihiko Soga","orcid":"0000-0001-5346-1474","position":0,"is_corresponding":true}],"reference_count":10,"raw_metadata":null,"created_at":"2026-07-19T02:09:27.134858Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}