{"doi":"10.7759/cureus.44805","title":"The First Sign of Recurrent Angioimmunoblastic T-Cell Lymphoma: A Cutaneous Presentation","abstract":null,"journal":"Cureus","year":2023,"id":621969,"datarank":0.20794415416798362,"base_score":1.3862943611198906,"endowment":1.3862943611198906,"self_citation_contribution":0.20794415416798362,"citation_network_contribution":0.0,"self_endowment_contribution":0.20794415416798362,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1606377,"name":"Michael McBride","orcid":null,"position":1,"is_corresponding":false},{"id":1606378,"name":"Amanda K Thomas","orcid":null,"position":2,"is_corresponding":false},{"id":1606379,"name":"Mitch Manway","orcid":null,"position":3,"is_corresponding":false},{"id":1606380,"name":"David J DiCaudo","orcid":null,"position":4,"is_corresponding":false},{"id":1606376,"name":"Guy Charest","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"The First Sign of Recurrent Angioimmunoblastic T-Cell Lymphoma: A Cutaneous Presentation","abstract":"Angioimmunoblastic T-cell lymphoma (AITL) is a subtype of peripheral T-cell lymphoma with a nonspecific clinical presentation. Cutaneous manifestations of AITL are variable and include morbilliform eruptions, urticaria, papulonodules, and erythroderma. We present the case of a 74-year-old male with a medical history of AITL presenting with diffuse erythematous macules and papules coalescing into patches and plaques on the trunk and bilateral upper extremities. Histopathology demonstrated a mild perivascular lymphocytic infiltrate in the dermis. By immunohistochemistry, the lymphocytic infiltrate was strongly positive for programmed cell death protein 1 (PD-1) (CD279) as well as cluster of differentiation 3 (CD3), CD5, and (focally) B-cell lymphoma-6 (BCL-6). Many cells within the infiltrate were positive for Epstein-Barr virus (EBV) by in situ hybridization. Additionally, a bone marrow biopsy demonstrated an atypical lymphoid infiltrate with T-cell predominance, many EBV-positive cells, and clonal T-cell receptor (TCR) beta gene rearrangement. Based on these histopathological findings, a diagnosis of recurrent AITL with cutaneous involvement was made. This case is a rare example of skin findings presenting as a first sign of recurrent AITL.","is_dataset_classified":null,"base_score":1.3862943611198906,"endowment":1.3862943611198906,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"37809113","pmcid":"PMC10558893","openalex_id":"https://openalex.org/W4386505367","authors":[],"funders":[],"total_grants":0,"fwci":0.6966,"citation_percentile":0.7339291,"influential_citations":0,"citation_trend":[{"year":2025,"count":1},{"year":2026,"count":2}],"oa_status":"gold","license":"cc-by","oa_locations":[{"url":"https://www.cureus.com/articles/185372-the-first-sign-of-recurrent-angioimmunoblastic-t-cell-lymphoma-a-cutaneous-presentation.pdf","host_type":"journal"},{"url":"https://www.cureus.com/articles/185372-the-first-sign-of-recurrent-angioimmunoblastic-t-cell-lymphoma-a-cutaneous-presentation.pdf","host_type":"publisher"},{"url":"https://www.cureus.com/articles/185372-the-first-sign-of-recurrent-angioimmunoblastic-t-cell-lymphoma-a-cutaneous-presentation","host_type":"publisher"},{"url":"http://dx.doi.org/10.7759/cureus.44805","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/37809113","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10558893","host_type":"repository"},{"url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10558893/pdf/cureus-0015-00000044805.pdf","host_type":"repository"},{"url":"https://assets.cureus.com/uploads/case_report/pdf/185372/20231007-22270-9ll01p.pdf","host_type":"Unpaywall"},{"url":"https://europepmc.org/articles/PMC10558893","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC10558893?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":["Cutaneous lymphoproliferative disorders research","Lymphoma Diagnosis and Treatment","Viral-associated cancers and disorders"],"mesh_terms":[],"keywords":["Angioimmunoblastic T-cell lymphoma","Pathology","Lymphoma","Medicine","Skin biopsy","CD5","Erythroderma","Cutaneous lymphoma","Peripheral T-cell lymphoma","Histopathology","Gene rearrangement","Biopsy","T cell","Biology","Mycosis fungoides","Immunology","Immune system","Epstein- Barr virus","Peripheral T Cell Lymphoma","Ptcl","Aitl","Angioimmunoblastic T Cell Lymphoma"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Zero hunger"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-03T17:30:53.298466Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}