{"doi":"10.7554/elife.98143","title":"Altered visual cortex excitatory/inhibitory ratio following transient congenital visual deprivation in humans","abstract":"<jats:p>Non-human animal models have indicated that the ratio of excitation to inhibition (E/I) in neural circuits is experience dependent, and changes across development. Here, we assessed 3T Magnetic Resonance Spectroscopy (MRS) and electroencephalography (EEG) markers of cortical E/I ratio in 10 individuals who had been treated for dense bilateral congenital cataracts, after an average of 12 years of blindness, to test for dependence of the E/I ratio on early visual experience in humans. First, participants underwent MRS scanning at rest with their eyes open and eyes closed, to obtain visual cortex Gamma-Aminobutyric Acid (GABA+) concentration, Glutamate/Glutamine (Glx) concentration, and the concentration ratio of Glx/GABA+, as measures of inhibition, excitation, and E/I ratio, respectively. Subsequently, EEG was recorded to assess aperiodic activity (1–20 Hz) as a neurophysiological measure of the cortical E/I ratio, during rest with eyes open and eyes closed, and during flickering stimulation. Across conditions, congenital cataract-reversal individuals demonstrated a significantly lower visual cortex Glx/GABA+ ratio, and a higher intercept and steeper aperiodic slope at occipital electrodes, compared to age-matched sighted controls. In the congenital cataract-reversal group, a lower Glx/GABA+ ratio was associated with better visual acuity, and Glx concentration correlated positively with the aperiodic intercept in the conditions with visual input. We speculate that these findings result from an increased E/I ratio of the visual cortex as a consequence of congenital blindness, which might require commensurately increased inhibition in order to balance the additional excitation from restored visual input. The lower E/I ratio in congenital cataract-reversal individuals would thus be a consequence of homeostatic plasticity.</jats:p>","journal":"eLife","year":2025,"id":641631,"datarank":0.16479184330021646,"base_score":1.0986122886681096,"endowment":1.0986122886681096,"self_citation_contribution":0.16479184330021646,"citation_network_contribution":0.0,"self_endowment_contribution":0.16479184330021646,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1668412,"name":"Kabilan Pitchaimuthu","orcid":"0000-0001-9090-5206","position":1,"is_corresponding":false},{"id":1668413,"name":"José P Ossandón","orcid":"0000-0002-2539-390X","position":2,"is_corresponding":false},{"id":1406226,"name":"Idris Shareef","orcid":"0000-0001-9258-2199","position":3,"is_corresponding":false},{"id":1668414,"name":"Sunitha Lingareddy","orcid":null,"position":4,"is_corresponding":false},{"id":628004,"name":"Jürgen Finsterbusch","orcid":"0000-0002-6077-8119","position":5,"is_corresponding":false},{"id":1668415,"name":"Ramesh Kekunnaya","orcid":"0000-0001-5789-2300","position":6,"is_corresponding":false},{"id":1668416,"name":"Brigitte Röder","orcid":"0000-0003-3088-8023","position":7,"is_corresponding":false},{"id":1177005,"name":"Rashi Pant","orcid":"0000-0001-5242-4145","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Altered visual cortex excitatory/inhibitory ratio following transient congenital visual deprivation in humans","abstract":"<jats:p>Non-human animal models have indicated that the ratio of excitation to inhibition (E/I) in neural circuits is experience dependent, and changes across development. Here, we assessed 3T Magnetic Resonance Spectroscopy (MRS) and electroencephalography (EEG) markers of cortical E/I ratio in 10 individuals who had been treated for dense bilateral congenital cataracts, after an average of 12 years of blindness, to test for dependence of the E/I ratio on early visual experience in humans. First, participants underwent MRS scanning at rest with their eyes open and eyes closed, to obtain visual cortex Gamma-Aminobutyric Acid (GABA+) concentration, Glutamate/Glutamine (Glx) concentration, and the concentration ratio of Glx/GABA+, as measures of inhibition, excitation, and E/I ratio, respectively. Subsequently, EEG was recorded to assess aperiodic activity (1–20 Hz) as a neurophysiological measure of the cortical E/I ratio, during rest with eyes open and eyes closed, and during flickering stimulation. Across conditions, congenital cataract-reversal individuals demonstrated a significantly lower visual cortex Glx/GABA+ ratio, and a higher intercept and steeper aperiodic slope at occipital electrodes, compared to age-matched sighted controls. In the congenital cataract-reversal group, a lower Glx/GABA+ ratio was associated with better visual acuity, and Glx concentration correlated positively with the aperiodic intercept in the conditions with visual input. We speculate that these findings result from an increased E/I ratio of the visual cortex as a consequence of congenital blindness, which might require commensurately increased inhibition in order to balance the additional excitation from restored visual input. The lower E/I ratio in congenital cataract-reversal individuals would thus be a consequence of homeostatic plasticity.</jats:p>","is_dataset_classified":null,"base_score":1.0986122886681096,"endowment":1.0986122886681096,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"40377962","pmcid":"PMC12084009","openalex_id":"https://openalex.org/W4399366023","authors":[],"funders":[{"funder_name":"Hector Fellow Academy","grant_id":"PhD Student Fellowship","title":null},{"funder_name":"Deutsche Forschungsgemeinschaft","grant_id":"DFG Ro 2625/10-1","title":null},{"funder_name":"Landesforschungsförderung","grant_id":"LFF-FV 6","title":null},{"funder_name":"Deutsche Forschungsgemeinschaft","grant_id":"SFB 936-178316478-B11","title":null},{"funder_name":"Deutsche Forschungsgemeinschaft","grant_id":"unidentified","title":"unidentified"},{"funder_name":"Deutsche Forschungsgemeinschaft","grant_id":"178316478/SFB 936","title":"Multi-site communication in the brain"}],"total_grants":6,"fwci":null,"citation_percentile":null,"influential_citations":0,"citation_trend":[{"year":2025,"count":2}],"oa_status":"gold","license":"cc-by","oa_locations":[{"url":"https://elifesciences.org/reviewed-preprints/98143.pdf","host_type":"journal"},{"url":"https://elifesciences.org/reviewed-preprints/98143.pdf","host_type":"publisher"},{"url":"https://cdn.elifesciences.org/articles/98143/elife-98143-v1.pdf","host_type":"publisher"},{"url":"https://cdn.elifesciences.org/articles/98143/elife-98143-v1.xml","host_type":"publisher"},{"url":"https://elifesciences.org/articles/98143","host_type":"publisher"},{"url":"https://doi.org/10.7554/elife.98143","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/40377962","host_type":"repository"},{"url":"https://doaj.org/article/f812d2d397b3493cb38129e64d29afc3","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12084009","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC12084009","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC12084009?pdf=render","host_type":"Europe_PMC"},{"url":"https://doi.org/10.7554/elife.98143.4","host_type":""},{"url":"https://doi.org/10.7554/elife.98143.3","host_type":""},{"url":"https://doi.org/10.1101/2024.04.18.590147","host_type":""},{"url":"https://doi.org/10.7554/elife.98143.1","host_type":""},{"url":"https://doi.org/10.7554/elife.98143.2","host_type":""},{"url":"http://dx.doi.org/10.7554/eLife.98143","host_type":""}],"fields_of_study":["Neural dynamics and brain function","Neuroscience and Neuropharmacology Research","Visual perception and processing mechanisms","03 medical and health sciences","0302 clinical medicine","Humans","Visual Cortex","Male","Female","Cataract","Electroencephalography","Adult","Magnetic Resonance Spectroscopy","Glutamic Acid","Glutamine","gamma-Aminobutyric Acid","Blindness","Young Adult","Sensory Deprivation"],"mesh_terms":["Adult","Blindness","Cataract","Electroencephalography","Female","gamma-Aminobutyric Acid","Glutamine","Humans","Male","Magnetic Resonance Spectroscopy","Sensory Deprivation","Visual Cortex","Glutamic Acid","Young Adult"],"keywords":["Visual cortex","Neuroscience","Excitatory postsynaptic potential","Cortex (anatomy)","Cortical blindness","Electroencephalography","Psychology","Inhibitory postsynaptic potential","Internal medicine","Medicine","Chemistry","Blindness","Human","Visual development","Plasticity","Visual deprivation","Sensitive Periods","Cataract Models","Excitatory/inhibitory Balance","Male","Adult","Magnetic Resonance Spectroscopy","QH301-705.5","Science","Glutamine","Glutamic Acid","Cataract","Young Adult","Humans","Biology (General)","gamma-Aminobutyric Acid","Q","R","Female","Sensory Deprivation"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-07T19:22:37.864183Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}