{"doi":"10.7554/elife.97767","title":"Mitochondrial stress in GABAergic neurons non-cell autonomously regulates organismal health and aging","abstract":"Abstract Mitochondrial stress within the nervous system can trigger non-cell autonomous responses in peripheral tissues. However, the specific neurons involved and their impact on organismal aging and health have remained incompletely understood. Here, we demonstrate that mitochondrial stress in γ-aminobutyric acid-producing (GABAergic) neurons in Caenorhabditis elegans (C. elegans) is sufficient to significantly alter organismal lifespan, stress tolerance, and reproductive capabilities. This mitochondrial stress also leads to significant changes in mitochondrial mass, energy production, and levels of reactive oxygen species (ROS). DAF-16/FoxO activity is enhanced by GABAergic neuronal mitochondrial stress and mediates the induction of these non-cell-autonomous effects. Moreover, our findings indicate that GABA signaling operates within the same pathway as mitochondrial stress in GABAergic neurons, resulting in non-cell-autonomous alterations in organismal stress tolerance and longevity. In summary, these data suggest the crucial role of GABAergic neurons in detecting mitochondrial stress and orchestrating non-cell-autonomous changes throughout the organism.","journal":"eLife","year":2024,"id":487030,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9501,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":662774,"name":"Shayla Curry","orcid":null,"position":1,"is_corresponding":false},{"id":453208,"name":"Youngyong Park","orcid":"0000-0003-0842-2403","position":2,"is_corresponding":false},{"id":380372,"name":"Taylor McElroy","orcid":"0000-0002-4924-9283","position":3,"is_corresponding":false},{"id":1084247,"name":"Briana Robles","orcid":null,"position":4,"is_corresponding":false},{"id":458335,"name":"Sheng Yi","orcid":"0000-0003-1316-3370","position":5,"is_corresponding":false},{"id":70352,"name":"Wei‐Wen Chen","orcid":"0000-0003-2234-5686","position":6,"is_corresponding":false},{"id":715289,"name":"Kisuk Min","orcid":"0000-0002-0355-3327","position":7,"is_corresponding":false},{"id":376197,"name":"Rui Xiao","orcid":"0000-0001-5541-6685","position":8,"is_corresponding":false},{"id":453210,"name":"Myon‐Hee Lee","orcid":"0000-0001-9020-2391","position":9,"is_corresponding":false},{"id":404808,"name":"Sung Min Han","orcid":"0000-0001-7442-754X","position":10,"is_corresponding":false},{"id":662772,"name":"Laxmi Rathor","orcid":null,"position":0,"is_corresponding":true}],"reference_count":123,"raw_metadata":null,"created_at":"2026-07-19T02:08:06.013846Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}