{"doi":"10.7554/elife.96812","title":"Neurotrophic factor Neuritin modulates T cell electrical and metabolic state for the balance of tolerance and immunity","abstract":"The adaptive T cell response is accompanied by continuous rewiring of the T cell’s electric and metabolic state. Ion channels and nutrient transporters integrate bioelectric and biochemical signals from the environment, setting cellular electric and metabolic states. Divergent electric and metabolic states contribute to T cell immunity or tolerance. Here, we report in mice that neuritin ( Nrn1 ) contributes to tolerance development by modulating regulatory and effector T cell function. Nrn1 expression in regulatory T cells promotes its expansion and suppression function, while expression in the T effector cell dampens its inflammatory response. Nrn1 deficiency in mice causes dysregulation of ion channel and nutrient transporter expression in Treg and effector T cells, resulting in divergent metabolic outcomes and impacting autoimmune disease progression and recovery. These findings identify a novel immune function of the neurotrophic factor Nrn1 in regulating the T cell metabolic state in a cell context-dependent manner and modulating the outcome of an immune response.","journal":"eLife","year":2024,"id":484892,"datarank":0.34638130073367523,"base_score":2.0794415416798357,"endowment":2.0794415416798357,"self_citation_contribution":0.31191623125197543,"citation_network_contribution":0.034465069481699785,"self_endowment_contribution":0.31191623125197543,"citer_contribution":0.034465069481699785,"corpus_percentile":null,"corpus_rank":null,"citation_count":7,"citer_count":6,"citers_with_citation_signal":4,"citers_with_endowment":4,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9546,"is_data_producer":true,"deposit_databanks":{"GEO":["GSE121908","GSE224083"]},"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1327027,"name":"Hiroshi Nishio","orcid":"0000-0002-4938-416X","position":1,"is_corresponding":false},{"id":628637,"name":"Joseph Barbi","orcid":"0000-0002-5632-0885","position":2,"is_corresponding":false},{"id":831905,"name":"Marisa Mitchell-Flack","orcid":"0000-0003-3192-0865","position":3,"is_corresponding":false},{"id":614547,"name":"Paolo Vignali","orcid":"0000-0002-0214-8629","position":4,"is_corresponding":false},{"id":1182410,"name":"Ying Zheng","orcid":"0000-0002-5264-6431","position":5,"is_corresponding":false},{"id":328390,"name":"Andriana Lebid","orcid":"0000-0002-8207-0605","position":6,"is_corresponding":false},{"id":1327028,"name":"Kwang‐Yu Chang","orcid":"0000-0002-5240-2760","position":7,"is_corresponding":false},{"id":514095,"name":"Juan Fu","orcid":null,"position":8,"is_corresponding":false},{"id":1327479,"name":"Makenzie Higgins","orcid":null,"position":9,"is_corresponding":false},{"id":1327029,"name":"Ching‐Tai Huang","orcid":"0000-0001-8624-4513","position":10,"is_corresponding":false},{"id":1327030,"name":"Xuehong Zhang","orcid":"0000-0001-8040-4141","position":11,"is_corresponding":false},{"id":620481,"name":"Zhiguang Li","orcid":"0000-0003-2474-3485","position":12,"is_corresponding":false},{"id":1327480,"name":"Lee Blosser","orcid":null,"position":13,"is_corresponding":false},{"id":228366,"name":"Ada Tam","orcid":"0000-0001-6828-5290","position":14,"is_corresponding":false},{"id":59423,"name":"Charles G. Drake","orcid":"0000-0001-9610-3677","position":15,"is_corresponding":false},{"id":59439,"name":"Drew M. Pardoll","orcid":"0000-0001-6215-1013","position":16,"is_corresponding":false},{"id":1327026,"name":"Hong Yu","orcid":"0000-0002-8778-9870","position":0,"is_corresponding":true}],"reference_count":91,"raw_metadata":null,"created_at":"2026-07-19T02:07:42.971417Z","pmid":"39565188","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}