{"doi":"10.7554/elife.94342","title":"The potassium channel subunit KV1.8 (Kcna10) is essential for the distinctive outwardly rectifying conductances of type I and II vestibular hair cells","abstract":"In amniotes, head motions and tilt are detected by two types of vestibular hair cells (HCs) with strikingly different morphology and physiology. Mature type I HCs express a large and very unusual potassium conductance, g K,L , which activates negative to resting potential, confers very negative resting potentials and low input resistances, and enhances an unusual non-quantal transmission from type I cells onto their calyceal afferent terminals. Following clues pointing to K V 1.8 ( Kcna10 ) in the Shaker K channel family as a candidate g K,L subunit, we compared whole-cell voltage-dependent currents from utricular HCs of K V 1.8-null mice and littermate controls. We found that K V 1.8 is necessary not just for g K,L but also for fast-inactivating and delayed rectifier currents in type II HCs, which activate positive to resting potential. The distinct properties of the three K V 1.8-dependent conductances may reflect different mixing with other K V subunits that are reported to be differentially expressed in type I and II HCs. In K V 1.8-null HCs of both types, residual outwardly rectifying conductances include K V 7 ( Knq ) channels. Current clamp records show that in both HC types, K V 1.8-dependent conductances increase the speed and damping of voltage responses. Features that speed up vestibular receptor potentials and non-quantal afferent transmission may have helped stabilize locomotion as tetrapods moved from water to land.","journal":"eLife","year":2024,"id":484064,"datarank":0.6071116632398263,"base_score":2.9444389791664403,"endowment":2.9444389791664403,"self_citation_contribution":0.44166584687496613,"citation_network_contribution":0.16544581636486017,"self_endowment_contribution":0.44166584687496613,"citer_contribution":0.16544581636486017,"corpus_percentile":null,"corpus_rank":null,"citation_count":18,"citer_count":13,"citers_with_citation_signal":8,"citers_with_endowment":8,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9477,"is_data_producer":true,"deposit_databanks":{"Dryad":["10.5061/dryad.37pvmcvrw"]},"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":497847,"name":"Anna Lysakowski","orcid":"0000-0001-6259-0294","position":1,"is_corresponding":false},{"id":279457,"name":"Ruth Anne Eatock","orcid":"0000-0001-7547-2051","position":2,"is_corresponding":false},{"id":1168355,"name":"Hannah R Martin","orcid":"0000-0003-2028-5798","position":0,"is_corresponding":true}],"reference_count":85,"raw_metadata":null,"created_at":"2026-07-19T02:07:38.055693Z","pmid":"39625061","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}