{"doi":"10.7554/elife.93172","title":"Exceptional longevity of mammalian ovarian and oocyte macromolecules throughout the reproductive lifespan","abstract":"The mechanisms contributing to age-related deterioration of the female reproductive system are complex, however aberrant protein homeostasis is a major contributor. We elucidated exceptionally stable proteins, structures, and macromolecules that persist in mammalian ovaries and gametes across the reproductive lifespan. Ovaries exhibit localized structural and cell-type-specific enrichment of stable macromolecules in both the follicular and extrafollicular environments. Moreover, ovaries and oocytes both harbor a panel of exceptionally long-lived proteins, including cytoskeletal, mitochondrial, and oocyte-derived proteins. The exceptional persistence of these long-lived molecules suggest a critical role in lifelong maintenance and age-dependent deterioration of reproductive tissues.","journal":"eLife","year":2024,"id":484313,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":11,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9419,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":899597,"name":"Karen M Velez","orcid":"0000-0002-9703-1684","position":1,"is_corresponding":false},{"id":273409,"name":"Luhan T. Zhou","orcid":"0000-0003-4757-0652","position":2,"is_corresponding":false},{"id":483479,"name":"Christelle Guillermier","orcid":"0000-0001-7268-3849","position":3,"is_corresponding":false},{"id":326702,"name":"Seby Edassery","orcid":"0000-0003-1129-748X","position":4,"is_corresponding":false},{"id":324246,"name":"Matthew L. Steinhauser","orcid":"0000-0001-5287-9246","position":5,"is_corresponding":false},{"id":326707,"name":"Jeffrey N. Savas","orcid":"0000-0002-8173-5580","position":6,"is_corresponding":false},{"id":273413,"name":"Francesca E. Duncan","orcid":"0000-0002-3756-9394","position":7,"is_corresponding":false},{"id":877452,"name":"Ewa Bomba-Warczak","orcid":"0000-0002-1744-3516","position":0,"is_corresponding":true}],"reference_count":66,"raw_metadata":null,"created_at":"2026-07-19T02:07:38.055693Z","pmid":"39480006","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}