{"doi":"10.7554/elife.87993.1","title":"SIRT-1 is required for release of enveloped picornaviruses","abstract":"Abstract Enterovirus D68 is a re-emerging enterovirus that causes acute respiratory illness in infants and has recently been linked to Acute Flaccid Myelitis. Here, we show that the histone deacetylase, SIRT-1, is essential for autophagy and EV-D68 infection. Knockdown of SIRT-1 blocks autophagy and reduces EV-D68 extracellular titers. The proviral activity of SIRT-1 does not require its deacetylase activity or functional autophagy. SIRT-1’s proviral activity is, we demonstrate, mediated through the repression of ER stress. Inducing ER stress through thapsigargin treatment or SERCA2A knockdown in SIRT-1 knockdown cells had no additional effect on EV-D68 extracellular titers. Knockdown of SIRT-1 also decreases poliovirus and SARS-CoV-2 titers but not coxsackievirus B3. In non-lytic conditions, EV-D68 is primarily released in an enveloped form, and SIRT-1 is required for this process. Our data show that SIRT-1, through its translocation to the cytosol, is critical to promote the release of enveloped EV-D68 viral particles.","journal":null,"year":2023,"id":409042,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9534,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":390596,"name":"James Logue","orcid":"0000-0002-7410-9741","position":1,"is_corresponding":false},{"id":474931,"name":"Stuart Weston","orcid":"0000-0001-9840-2953","position":2,"is_corresponding":false},{"id":1006703,"name":"Michael A. Wagner","orcid":"0000-0002-4161-184X","position":3,"is_corresponding":false},{"id":1006704,"name":"Ganna Galitska","orcid":"0000-0001-9365-6751","position":4,"is_corresponding":false},{"id":1006705,"name":"Katelyn Miller","orcid":"0000-0002-8893-7011","position":5,"is_corresponding":false},{"id":218418,"name":"Matthew B. Frieman","orcid":"0000-0003-0107-0775","position":6,"is_corresponding":false},{"id":250773,"name":"William T. Jackson","orcid":"0000-0002-9832-0584","position":7,"is_corresponding":false},{"id":417726,"name":"Alagie Jassey","orcid":"0009-0001-3669-3836","position":0,"is_corresponding":true}],"reference_count":41,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T01:21:22.368387Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}