{"doi":"10.7554/elife.87705","title":"Searching for molecular hypoxia sensors among oxygen-dependent enzymes","abstract":"The ability to sense and respond to changes in cellular oxygen levels is critical for aerobic organisms and requires a molecular oxygen sensor. The prototypical sensor is the oxygen-dependent enzyme PHD: hypoxia inhibits its ability to hydroxylate the transcription factor HIF, causing HIF to accumulate and trigger the classic HIF-dependent hypoxia response. A small handful of other oxygen sensors are known, all of which are oxygen-dependent enzymes. However, hundreds of oxygen-dependent enzymes exist among aerobic organisms, raising the possibility that additional sensors remain to be discovered. This review summarizes known and potential hypoxia sensors among human O 2 -dependent enzymes and highlights their possible roles in hypoxia-related adaptation and diseases.","journal":"eLife","year":2023,"id":321457,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":44,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9512,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1033557,"name":"Susan Q. Shen","orcid":"0000-0001-5558-294X","position":1,"is_corresponding":false},{"id":805802,"name":"Philip E. Bickler","orcid":"0000-0002-5077-4982","position":2,"is_corresponding":false},{"id":272025,"name":"Matthew P. Jacobson","orcid":"0000-0001-6262-655X","position":3,"is_corresponding":false},{"id":483451,"name":"Lani F. Wu","orcid":"0000-0002-0052-7537","position":4,"is_corresponding":false},{"id":483452,"name":"Steven J. Altschuler","orcid":"0000-0001-9142-0796","position":5,"is_corresponding":false},{"id":1033556,"name":"Li Li","orcid":"0000-0002-1018-104X","position":0,"is_corresponding":true}],"reference_count":263,"raw_metadata":null,"created_at":"2026-07-19T01:07:32.611759Z","pmid":"37494095","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}