{"doi":"10.7554/elife.87430","title":"β-Carotene accelerates the resolution of atherosclerosis in mice","abstract":"β-Carotene oxygenase 1 (BCO1) catalyzes the cleavage of β-carotene to form vitamin A. Besides its role in vision, vitamin A regulates the expression of genes involved in lipid metabolism and immune cell differentiation. BCO1 activity is associated with the reduction of plasma cholesterol in humans and mice, while dietary β-carotene reduces hepatic lipid secretion and delays atherosclerosis progression in various experimental models. Here we show that β-carotene also accelerates atherosclerosis resolution in two independent murine models, independently of changes in body weight gain or plasma lipid profile. Experiments in Bco1 -/- mice implicate vitamin A production in the effects of β-carotene on atherosclerosis resolution. To explore the direct implication of dietary β-carotene on regulatory T cells (Tregs) differentiation, we utilized anti-CD25 monoclonal antibody infusions. Our data show that β-carotene favors Treg expansion in the plaque, and that the partial inhibition of Tregs mitigates the effect of β-carotene on atherosclerosis resolution. Our data highlight the potential of β-carotene and BCO1 activity in the resolution of atherosclerotic cardiovascular disease.","journal":"eLife","year":2023,"id":344474,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":13,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9549,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":314678,"name":"Johana Coronel","orcid":"0000-0002-9257-0849","position":1,"is_corresponding":false},{"id":1083279,"name":"Asma’a Albakri","orcid":null,"position":2,"is_corresponding":false},{"id":1082887,"name":"Amparo Blanco","orcid":"0009-0000-8819-3131","position":3,"is_corresponding":false},{"id":1083280,"name":"Patrick McQueen","orcid":null,"position":4,"is_corresponding":false},{"id":1082888,"name":"Donald Molina","orcid":"0000-0003-4100-027X","position":5,"is_corresponding":false},{"id":1083281,"name":"JaeYoung Sim","orcid":null,"position":6,"is_corresponding":false},{"id":94623,"name":"Edward A. Fisher","orcid":"0000-0001-9802-143X","position":7,"is_corresponding":false},{"id":244024,"name":"Jaume Amengual","orcid":null,"position":8,"is_corresponding":false},{"id":355866,"name":"Ivan Pinos","orcid":"0000-0002-2236-8936","position":0,"is_corresponding":true}],"reference_count":87,"raw_metadata":null,"created_at":"2026-07-19T01:11:30.951510Z","pmid":"38319073","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}