{"doi":"10.7554/elife.84394","title":"Multi-ancestry meta-analysis of host genetic susceptibility to tuberculosis identifies shared genetic architecture","abstract":"The heritability of susceptibility to tuberculosis (TB) disease has been well recognized. Over 100 genes have been studied as candidates for TB susceptibility, and several variants were identified by genome-wide association studies (GWAS), but few replicate. We established the International Tuberculosis Host Genetics Consortium to perform a multi-ancestry meta-analysis of GWAS, including 14,153 cases and 19,536 controls of African, Asian, and European ancestry. Our analyses demonstrate a substantial degree of heritability (pooled polygenic h 2 = 26.3%, 95% CI 23.7–29.0%) for susceptibility to TB that is shared across ancestries, highlighting an important host genetic influence on disease. We identified one global host genetic correlate for TB at genome-wide significance (p<5 × 10 -8 ) in the human leukocyte antigen (HLA)-II region (rs28383206, p-value=5.2 × 10 -9 ) but failed to replicate variants previously associated with TB susceptibility. These data demonstrate the complex shared genetic architecture of susceptibility to TB and the importance of large-scale GWAS analysis across multiple ancestries experiencing different levels of infection pressure.","journal":"eLife","year":2023,"id":322590,"datarank":0.7423223621835644,"base_score":3.713572066704308,"endowment":3.713572066704308,"self_citation_contribution":0.5570358100056463,"citation_network_contribution":0.18528655217791815,"self_endowment_contribution":0.5570358100056463,"citer_contribution":0.18528655217791815,"corpus_percentile":null,"corpus_rank":null,"citation_count":40,"citer_count":29,"citers_with_citation_signal":9,"citers_with_endowment":9,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9066,"is_data_producer":true,"deposit_databanks":{"Dryad":["10.5061/dryad.6wwpzgn2s"]},"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":292648,"name":"Vivek Naranbhai","orcid":"0000-0003-4281-8882","position":1,"is_corresponding":false},{"id":749603,"name":"Tom Yates","orcid":"0000-0002-6081-1767","position":2,"is_corresponding":false},{"id":988186,"name":"James J. Gilchrist","orcid":"0000-0003-2045-6788","position":3,"is_corresponding":false},{"id":247491,"name":"Tom Parks","orcid":"0000-0002-1163-8654","position":4,"is_corresponding":false},{"id":438383,"name":"Peter J. Dodd","orcid":"0000-0001-5825-9347","position":5,"is_corresponding":false},{"id":457018,"name":"Marlo Möller","orcid":"0000-0002-0805-6741","position":6,"is_corresponding":false},{"id":457017,"name":"Eileen G. Hoal","orcid":"0000-0002-6444-5688","position":7,"is_corresponding":false},{"id":16092,"name":"Andrew P. Morris","orcid":"0000-0002-6805-6014","position":8,"is_corresponding":false},{"id":51088,"name":"Adrian V. S. Hill","orcid":"0000-0003-0900-9629","position":9,"is_corresponding":false},{"id":988185,"name":"Haiko Schurz","orcid":"0000-0002-0009-3409","position":0,"is_corresponding":true}],"reference_count":86,"raw_metadata":null,"created_at":"2026-07-19T01:07:42.497873Z","pmid":"38224499","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}