{"doi":"10.7554/elife.84238","title":"Pleiotropic effects of BAFF on the senescence-associated secretome and growth arrest","abstract":"Senescent cells release a variety of cytokines, proteases, and growth factors collectively known as the senescence-associated secretory phenotype (SASP). Sustained SASP contributes to a pattern of chronic inflammation associated with aging and implicated in many age-related diseases. Here, we investigated the expression and function of the immunomodulatory cytokine BAFF (B-cell activating factor; encoded by the TNFSF13B gene), a SASP protein, in multiple senescence models. We first characterized BAFF production across different senescence paradigms, including senescent human diploid fibroblasts (WI-38, IMR-90) and monocytic leukemia cells (THP-1), and tissues of mice induced to undergo senescence. We then identified IRF1 (interferon regulatory factor 1) as a transcription factor required for promoting TNFSF13B mRNA transcription in senescence. We discovered that suppressing BAFF production decreased the senescent phenotype of both fibroblasts and monocyte-like cells, reducing IL6 secretion and SA-β-Gal staining. Importantly, however, the influence of BAFF on the senescence program was cell type-specific: in monocytes, BAFF promoted the early activation of NF-κB and general SASP secretion, while in fibroblasts, BAFF contributed to the production and function of TP53 (p53). We propose that BAFF is elevated across senescence models and is a potential target for senotherapy.","journal":"eLife","year":2023,"id":337175,"datarank":0.6433899369426799,"base_score":2.9444389791664403,"endowment":2.9444389791664403,"self_citation_contribution":0.44166584687496613,"citation_network_contribution":0.2017240900677138,"self_endowment_contribution":0.44166584687496613,"citer_contribution":0.2017240900677138,"corpus_percentile":null,"corpus_rank":null,"citation_count":18,"citer_count":15,"citers_with_citation_signal":12,"citers_with_endowment":12,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9592,"is_data_producer":true,"deposit_databanks":{"GEO":["GSE213993"]},"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":254790,"name":"Carlos Anerillas","orcid":"0000-0003-4424-7913","position":1,"is_corresponding":false},{"id":249140,"name":"Maria Laura Idda","orcid":"0000-0001-5243-8977","position":2,"is_corresponding":false},{"id":252579,"name":"Rachel Munk","orcid":null,"position":3,"is_corresponding":false},{"id":573308,"name":"Chang Hoon Shin","orcid":null,"position":4,"is_corresponding":false},{"id":890571,"name":"Stefano Donegà","orcid":"0000-0003-0669-1618","position":5,"is_corresponding":false},{"id":276700,"name":"Dimitrios Tsitsipatis","orcid":null,"position":6,"is_corresponding":false},{"id":298506,"name":"Allison B. Herman","orcid":"0000-0003-3826-3247","position":7,"is_corresponding":false},{"id":275718,"name":"Jennifer L. Martindale","orcid":"0000-0002-3234-6861","position":8,"is_corresponding":false},{"id":276701,"name":"Xiaoling Yang","orcid":null,"position":9,"is_corresponding":false},{"id":306454,"name":"Yulan Piao","orcid":null,"position":10,"is_corresponding":false},{"id":298507,"name":"Krystyna Mazan-Mamczarz","orcid":"0009-0005-1545-0500","position":11,"is_corresponding":false},{"id":752633,"name":"Jinshui Fan","orcid":"0009-0001-9300-1920","position":12,"is_corresponding":false},{"id":21956,"name":"Luigi Ferrucci","orcid":"0000-0002-6273-1613","position":13,"is_corresponding":false},{"id":477626,"name":"Peter F. Johnson","orcid":"0000-0002-4145-4725","position":14,"is_corresponding":false},{"id":275722,"name":"Supriyo De","orcid":"0000-0002-2075-7655","position":15,"is_corresponding":false},{"id":249142,"name":"Kotb Abdelmohsen","orcid":"0000-0001-6240-5810","position":16,"is_corresponding":false},{"id":218108,"name":"Myriam Gorospe","orcid":"0000-0001-5439-3434","position":17,"is_corresponding":false},{"id":249143,"name":"Martina Rossi","orcid":"0000-0001-7738-9841","position":0,"is_corresponding":true}],"reference_count":73,"raw_metadata":null,"created_at":"2026-07-19T01:10:26.690308Z","pmid":"37083495","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}