{"doi":"10.7554/elife.83908","title":"Germinal center B cells that acquire nuclear proteins are specifically suppressed by follicular regulatory T cells","abstract":"Follicular regulatory T cells (Tfr) restrict development of autoantibodies and autoimmunity while supporting high-affinity foreign antigen-specific humoral response. However, whether Tfr can directly repress germinal center (GC) B cells that acquire autoantigens is unclear. Moreover, TCR specificity of Tfr to self-antigens is not known. Our study suggests that nuclear proteins contain antigens specific to Tfr. Targeting of these proteins to antigen-specific B cells in mice triggers rapid accumulation of Tfr with immunosuppressive characteristics. Tfr then exert negative regulation of GC B cells with predominant inhibition of the nuclear protein-acquiring GC B cells, suggesting an important role of direct cognate Tfr-GC B cells interactions for the control of effector B cell response.","journal":"eLife","year":2023,"id":338118,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":17,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9483,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":505997,"name":"Zachary Benet","orcid":"0000-0002-8679-7545","position":1,"is_corresponding":false},{"id":674982,"name":"Mitra P. Maz","orcid":"0000-0002-2359-0862","position":2,"is_corresponding":false},{"id":677051,"name":"Jianhua Liu","orcid":"0000-0003-3585-6557","position":3,"is_corresponding":false},{"id":270442,"name":"Alexander L. Dent","orcid":"0000-0001-7226-8936","position":4,"is_corresponding":false},{"id":233184,"name":"J. Michelle Kahlenberg","orcid":"0000-0002-4006-8945","position":5,"is_corresponding":false},{"id":301029,"name":"Irina Grigorova","orcid":"0000-0002-4963-7403","position":6,"is_corresponding":false},{"id":1070496,"name":"Fang Ke","orcid":"0000-0001-8011-147X","position":0,"is_corresponding":true}],"reference_count":43,"raw_metadata":null,"created_at":"2026-07-19T01:10:35.973121Z","pmid":"36862132","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}