{"doi":"10.7554/elife.82947","title":"Mechanism of Ca2+ transport by ferroportin","abstract":"Ferroportin (Fpn) is a transporter that releases ferrous ion (Fe 2+ ) from cells and is important for homeostasis of iron in circulation. Export of one Fe 2+ by Fpn is coupled to import of two H + to maintain charge balance. Here, we show that human Fpn (HsFpn) binds to and mediates Ca 2+ transport. We determine the structure of Ca 2+ -bound HsFpn and identify a single Ca 2+ binding site distinct from the Fe 2+ binding sites. Further studies validate the Ca 2+ binding site and show that Ca 2+ transport is not coupled to transport of another ion. In addition, Ca 2+ transport is significantly inhibited in the presence of Fe 2+ but not vice versa. Function of Fpn as a Ca 2+ uniporter may allow regulation of iron homeostasis by Ca 2+ .","journal":"eLife","year":2023,"id":335856,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":19,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9582,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":996940,"name":"Azaan Saalim Wilbon","orcid":null,"position":1,"is_corresponding":false},{"id":297721,"name":"Ming Zhou","orcid":"0000-0001-7198-165X","position":2,"is_corresponding":false},{"id":297715,"name":"Yaping Pan","orcid":"0000-0001-7459-4217","position":3,"is_corresponding":false},{"id":297716,"name":"Jiemin Shen","orcid":"0000-0002-3977-0681","position":0,"is_corresponding":true}],"reference_count":36,"raw_metadata":null,"created_at":"2026-07-19T01:10:02.777338Z","pmid":"36648329","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}