{"doi":"10.7554/elife.80447","title":"Regulation of store-operated Ca2+ entry by IP3 receptors independent of their ability to release Ca2+","abstract":"\n Loss of endoplasmic reticular (ER) Ca\n 2+\n activates store-operated Ca\n 2+\n entry (SOCE) by causing the ER localized Ca\n 2+\n sensor STIM to unfurl domains that activate Orai channels in the plasma membrane at membrane contact sites (MCS). Here, we demonstrate a novel mechanism by which the inositol 1,4,5 trisphosphate receptor (IP\n 3\n R), an ER-localized IP\n 3\n -gated Ca\n 2+\n channel, regulates neuronal SOCE. In human neurons, SOCE evoked by pharmacological depletion of ER-Ca\n 2+\n is attenuated by loss of IP\n 3\n Rs, and restored by expression of IP\n 3\n Rs even when they cannot release Ca\n 2+\n , but only if the IP\n 3\n Rs can bind IP\n 3\n . Imaging studies demonstrate that IP\n 3\n Rs enhance association of STIM1 with Orai1 in neuronal cells with empty stores; this requires an IP\n 3\n -binding site, but not a pore. Convergent regulation by IP\n 3\n Rs, may tune neuronal SOCE to respond selectively to receptors that generate IP\n 3\n .\n ","journal":"eLife","year":2023,"id":24794,"datarank":0.7166599526301358,"base_score":3.332204510175204,"endowment":3.332204510175204,"self_citation_contribution":0.49983067652628066,"citation_network_contribution":0.21682927610385513,"self_endowment_contribution":0.49983067652628066,"citer_contribution":0.21682927610385513,"corpus_percentile":null,"corpus_rank":null,"citation_count":27,"citer_count":22,"citers_with_citation_signal":13,"citers_with_endowment":13,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":147714,"name":"Bipan Kumar 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