{"doi":"10.7554/elife.78280","title":"Glia-neuron coupling via a bipartite sialylation pathway promotes neural transmission and stress tolerance in Drosophila","abstract":"Modification by sialylated glycans can affect protein functions, underlying mechanisms that control animal development and physiology. Sialylation relies on a dedicated pathway involving evolutionarily conserved enzymes, including CMP-sialic acid synthetase (CSAS) and sialyltransferase (SiaT) that mediate the activation of sialic acid and its transfer onto glycan termini, respectively. In Drosophila , CSAS and DSiaT genes function in the nervous system, affecting neural transmission and excitability. We found that these genes function in different cells: the function of CSAS is restricted to glia, while DSiaT functions in neurons. This partition of the sialylation pathway allows for regulation of neural functions via a glia-mediated control of neural sialylation. The sialylation genes were shown to be required for tolerance to heat and oxidative stress and for maintenance of the normal level of voltage-gated sodium channels. Our results uncovered a unique bipartite sialylation pathway that mediates glia-neuron coupling and regulates neural excitability and stress tolerance.","journal":"eLife","year":2023,"id":353701,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":7,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.951,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1054260,"name":"Boris Novikov","orcid":"0009-0007-0458-8445","position":1,"is_corresponding":false},{"id":56623,"name":"Berrak Uğur","orcid":"0000-0003-4806-8891","position":2,"is_corresponding":false},{"id":1100837,"name":"Brooke Allen","orcid":null,"position":3,"is_corresponding":false},{"id":1100383,"name":"И. Б. Мерцалов","orcid":"0000-0001-9175-0592","position":4,"is_corresponding":false},{"id":1054259,"name":"Pedro Monagas-Valentin","orcid":"0000-0001-9671-5454","position":5,"is_corresponding":false},{"id":1054724,"name":"Melissa Koff","orcid":null,"position":6,"is_corresponding":false},{"id":1100838,"name":"Sarah Baas Robinson","orcid":null,"position":7,"is_corresponding":false},{"id":227811,"name":"Kazuhiro Aoki","orcid":"0000-0003-0029-4291","position":8,"is_corresponding":false},{"id":1100839,"name":"Raisa Veizaj","orcid":null,"position":9,"is_corresponding":false},{"id":314232,"name":"Dirk J. Lefeber","orcid":"0000-0001-7770-8398","position":10,"is_corresponding":false},{"id":227814,"name":"Michael Tiemeyer","orcid":"0000-0002-8704-9143","position":11,"is_corresponding":false},{"id":20909,"name":"Hugo J. Bellen","orcid":"0000-0001-5992-5989","position":12,"is_corresponding":false},{"id":1054262,"name":"Vladislav M. Panin","orcid":"0000-0001-9126-1481","position":13,"is_corresponding":false},{"id":1100382,"name":"Hilary Scott","orcid":"0000-0001-7064-4934","position":0,"is_corresponding":true}],"reference_count":91,"raw_metadata":null,"created_at":"2026-07-19T01:13:02.680107Z","pmid":"36946697","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}