{"doi":"10.7554/elife.68466","title":"LIN37-DREAM prevents DNA end resection and homologous recombination at DNA double-strand breaks in quiescent cells","abstract":"DNA double-strand break (DSB) repair by homologous recombination (HR) is thought to be restricted to the S- and G 2 - phases of the cell cycle in part due to 53BP1 antagonizing DNA end resection in G 1 -phase and non-cycling quiescent (G 0 ) cells. Here, we show that LIN37, a component of the DREAM transcriptional repressor, functions in a 53BP1-independent manner to prevent DNA end resection and HR in G 0 cells. Loss of LIN37 leads to the expression of HR proteins, including BRCA1, BRCA2, PALB2, and RAD51, and promotes DNA end resection in G 0 cells even in the presence of 53BP1. In contrast to 53BP1-deficiency, DNA end resection in LIN37-deficient G 0 cells depends on BRCA1 and leads to RAD51 filament formation and HR. LIN37 is not required to protect DNA ends in cycling cells at G 1 -phase. Thus, LIN37 regulates a novel 53BP1-independent cell phase-specific DNA end protection pathway that functions uniquely in quiescent cells.","journal":"eLife","year":2021,"id":172817,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":25,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9525,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":704489,"name":"Yinan Wang","orcid":"0000-0001-8030-9494","position":1,"is_corresponding":false},{"id":246620,"name":"Anthony Tubbs","orcid":"0000-0002-5605-8231","position":2,"is_corresponding":false},{"id":458971,"name":"Dali Zong","orcid":"0000-0001-6019-2970","position":3,"is_corresponding":false},{"id":709275,"name":"Faith Fowler","orcid":"0000-0002-7180-8141","position":4,"is_corresponding":false},{"id":652927,"name":"Nicholas Zolnerowich","orcid":"0000-0003-0033-4003","position":5,"is_corresponding":false},{"id":246623,"name":"Wei Wu","orcid":"0000-0001-5164-2765","position":6,"is_corresponding":false},{"id":709684,"name":"Amelia Bennett","orcid":null,"position":7,"is_corresponding":false},{"id":704488,"name":"Chun-Chin Chen","orcid":"0000-0001-8247-8734","position":8,"is_corresponding":false},{"id":709685,"name":"Wendy Feng","orcid":null,"position":9,"is_corresponding":false},{"id":248586,"name":"André Nussenzweig","orcid":null,"position":10,"is_corresponding":false},{"id":675415,"name":"Jessica K. Tyler","orcid":"0000-0001-9765-1659","position":11,"is_corresponding":false},{"id":244456,"name":"Barry P. Sleckman","orcid":"0000-0001-8295-4462","position":12,"is_corresponding":false},{"id":415570,"name":"Bo-Ruei Chen","orcid":"0000-0001-6404-2099","position":0,"is_corresponding":true}],"reference_count":51,"raw_metadata":null,"created_at":"2026-07-18T23:46:41.424716Z","pmid":"34477552","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}