{"doi":"10.7554/elife.68181","title":"Spatially displaced excitation contributes to the encoding of interrupted motion by a retinal direction-selective circuit","abstract":"Spatially distributed excitation and inhibition collectively shape a visual neuron's receptive field (RF) properties. In the direction-selective circuit of the mammalian retina, the role of strong null-direction inhibition of On-Off direction-selective ganglion cells (On-Off DSGCs) on their direction selectivity is well-studied. However, how excitatory inputs influence the On-Off DSGC's visual response is underexplored. Here, we report that On-Off DSGCs have a spatially displaced glutamatergic receptive field along their horizontal preferred-null motion axes. This displaced receptive field contributes to DSGC null-direction spiking during interrupted motion trajectories. Theoretical analyses indicate that population responses during interrupted motion may help populations of On-Off DSGCs signal the spatial location of moving objects in complex, naturalistic visual environments. Our study highlights that the direction-selective circuit exploits separate sets of mechanisms under different stimulus conditions, and these mechanisms may help encode multiple visual features.","journal":"eLife","year":2021,"id":200145,"datarank":0.41001459022143966,"base_score":2.1972245773362196,"endowment":2.1972245773362196,"self_citation_contribution":0.32958368660043297,"citation_network_contribution":0.08043090362100667,"self_endowment_contribution":0.32958368660043297,"citer_contribution":0.08043090362100667,"corpus_percentile":null,"corpus_rank":null,"citation_count":8,"citer_count":5,"citers_with_citation_signal":5,"citers_with_endowment":5,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9469,"is_data_producer":true,"deposit_databanks":{"Dryad":["10.5061/dryad.vq83bk3s8"]},"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":582205,"name":"Albert Chen","orcid":"0000-0002-9306-8703","position":1,"is_corresponding":false},{"id":582825,"name":"Janet Chung","orcid":null,"position":2,"is_corresponding":false},{"id":582206,"name":"Héctor Acarón Ledesma","orcid":"0000-0002-3138-1235","position":3,"is_corresponding":false},{"id":582826,"name":"Mofei Wu","orcid":null,"position":4,"is_corresponding":false},{"id":560260,"name":"David M. Berson","orcid":"0000-0002-3827-0079","position":5,"is_corresponding":false},{"id":290926,"name":"Stephanie E. Palmer","orcid":"0000-0001-6211-6293","position":6,"is_corresponding":false},{"id":414431,"name":"Wei Wei","orcid":"0000-0002-7771-5974","position":7,"is_corresponding":false},{"id":582204,"name":"Jennifer Ding","orcid":"0000-0003-2282-6615","position":0,"is_corresponding":true}],"reference_count":73,"raw_metadata":null,"created_at":"2026-07-18T23:50:44.479665Z","pmid":"34096504","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}