{"doi":"10.7554/elife.62952","title":"A cross-sectional study of functional and metabolic changes during aging through the lifespan in male mice","abstract":"Aging is associated with distinct phenotypical, physiological, and functional changes, leading to disease and death. The progression of aging-related traits varies widely among individuals, influenced by their environment, lifestyle, and genetics. In this study, we conducted physiologic and functional tests cross-sectionally throughout the entire lifespan of male C57BL/6N mice. In parallel, metabolomics analyses in serum, brain, liver, heart, and skeletal muscle were also performed to identify signatures associated with frailty and age-dependent functional decline. Our findings indicate that declines in gait speed as a function of age and frailty are associated with a dramatic increase in the energetic cost of physical activity and decreases in working capacity. Aging and functional decline prompt organs to rewire their metabolism and substrate selection and toward redox-related pathways, mainly in liver and heart. Collectively, the data provide a framework to further understand and characterize processes of aging at the individual organism and organ levels.","journal":"eLife","year":2021,"id":150092,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":97,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.6347,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":315392,"name":"Irene Alfaras","orcid":"0000-0002-2073-9641","position":1,"is_corresponding":false},{"id":639454,"name":"Melissa Krawcyzk","orcid":null,"position":2,"is_corresponding":false},{"id":638271,"name":"Woei-Nan Bair","orcid":"0000-0003-3517-3123","position":3,"is_corresponding":false},{"id":258545,"name":"Sarah J. Mitchell","orcid":"0000-0002-4027-3754","position":4,"is_corresponding":false},{"id":559076,"name":"Christopher H. Morrell","orcid":"0000-0001-5080-7142","position":5,"is_corresponding":false},{"id":295696,"name":"Stephanie A. Studenski","orcid":"0000-0003-2133-6235","position":6,"is_corresponding":false},{"id":291047,"name":"Nathan L. Price","orcid":"0000-0002-2821-9608","position":7,"is_corresponding":false},{"id":291051,"name":"Kenneth W. Fishbein","orcid":"0000-0002-6353-4603","position":8,"is_corresponding":false},{"id":291058,"name":"Richard G. Spencer","orcid":"0000-0001-7101-4328","position":9,"is_corresponding":false},{"id":228955,"name":"Morten Scheibye‐Knudsen","orcid":"0000-0002-6637-1280","position":10,"is_corresponding":false},{"id":55700,"name":"Edward G. Lakatta","orcid":"0000-0002-4772-0035","position":11,"is_corresponding":false},{"id":21956,"name":"Luigi Ferrucci","orcid":"0000-0002-6273-1613","position":12,"is_corresponding":false},{"id":258544,"name":"Miguel A. Aon","orcid":"0000-0002-4355-5431","position":13,"is_corresponding":false},{"id":115050,"name":"Michel Bernier","orcid":"0000-0002-5948-368X","position":14,"is_corresponding":false},{"id":258549,"name":"Rafael de Cabo","orcid":"0000-0003-2830-5693","position":15,"is_corresponding":false},{"id":291048,"name":"Michael Petr","orcid":"0000-0002-1808-0163","position":0,"is_corresponding":true}],"reference_count":48,"raw_metadata":null,"created_at":"2026-07-18T23:43:01.325389Z","pmid":"33876723","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}