{"doi":"10.7554/elife.60917","title":"A prion accelerates proliferation at the expense of lifespan","abstract":"In fluctuating environments, switching between different growth strategies, such as those affecting cell size and proliferation, can be advantageous to an organism. Trade-offs arise, however. Mechanisms that aberrantly increase cell size or proliferation—such as mutations or chemicals that interfere with growth regulatory pathways—can also shorten lifespan. Here we report a natural example of how the interplay between growth and lifespan can be epigenetically controlled. We find that a highly conserved RNA-modifying enzyme, the pseudouridine synthase Pus4/TruB, can act as a prion, endowing yeast with greater proliferation rates at the cost of a shortened lifespan. Cells harboring the prion grow larger and exhibit altered protein synthesis. This epigenetic state, [ BIG + ] ( b etter i n g rowth), allows cells to heritably yet reversibly alter their translational program, leading to the differential synthesis of dozens of proteins, including many that regulate proliferation and aging. Our data reveal a new role for prion-based control of an RNA-modifying enzyme in driving heritable epigenetic states that transform cell growth and survival.","journal":"eLife","year":2021,"id":176730,"datarank":0.8910142236018568,"base_score":3.091042453358316,"endowment":3.091042453358316,"self_citation_contribution":0.4636563680037475,"citation_network_contribution":0.4273578555981093,"self_endowment_contribution":0.4636563680037475,"citer_contribution":0.4273578555981093,"corpus_percentile":null,"corpus_rank":null,"citation_count":21,"citer_count":18,"citers_with_citation_signal":17,"citers_with_endowment":17,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9472,"is_data_producer":true,"deposit_databanks":{"GEO":["GSE176577"]},"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":576396,"name":"E. Campbell","orcid":null,"position":1,"is_corresponding":false},{"id":575538,"name":"Christopher M. Jakobson","orcid":"0000-0001-7594-7416","position":2,"is_corresponding":false},{"id":468640,"name":"Mitsuhiro Tsuchiya","orcid":null,"position":3,"is_corresponding":false},{"id":720108,"name":"Ethan A. Shaw (23811802)","orcid":null,"position":4,"is_corresponding":false},{"id":568694,"name":"Acadia DiNardo","orcid":"0000-0003-3219-4105","position":5,"is_corresponding":false},{"id":287812,"name":"Matt Kaeberlein","orcid":"0000-0002-1311-3421","position":6,"is_corresponding":false},{"id":282313,"name":"Daniel F. Jarosz","orcid":"0000-0003-3497-5888","position":7,"is_corresponding":false},{"id":575537,"name":"David M. Garcia","orcid":"0000-0003-0600-9527","position":0,"is_corresponding":true}],"reference_count":160,"raw_metadata":null,"created_at":"2026-07-18T23:47:23.605867Z","pmid":"34545808","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}