{"doi":"10.7554/elife.60259","title":"Caenorhabditis elegans methionine/S-adenosylmethionine cycle activity is sensed and adjusted by a nuclear hormone receptor","abstract":"Vitamin B12 is an essential micronutrient that functions in two metabolic pathways: the canonical propionate breakdown pathway and the methionine/S-adenosylmethionine (Met/SAM) cycle. In Caenorhabditis elegans, low vitamin B12, or genetic perturbation of the canonical propionate breakdown pathway results in propionate accumulation and the transcriptional activation of a propionate shunt pathway. This propionate-dependent mechanism requires nhr-10 and is referred to as ‘B12-mechanism-I’. Here, we report that vitamin B12 represses the expression of Met/SAM cycle genes by a propionate-independent mechanism we refer to as ‘B12-mechanism-II’. This mechanism is activated by perturbations in the Met/SAM cycle, genetically or due to low dietary vitamin B12. B12-mechanism-II requires nhr-114 to activate Met/SAM cycle gene expression, the vitamin B12 transporter, pmp-5 , and adjust influx and efflux of the cycle by activating msra-1 and repressing cbs-1 , respectively. Taken together, Met/SAM cycle activity is sensed and transcriptionally adjusted to be in a tight metabolic regime.","journal":"eLife","year":2020,"id":58379,"datarank":1.7339866745536052,"base_score":4.304065093204169,"endowment":4.304065093204169,"self_citation_contribution":0.6456097639806255,"citation_network_contribution":1.0883769105729797,"self_endowment_contribution":0.6456097639806255,"citer_contribution":1.0883769105729797,"corpus_percentile":null,"corpus_rank":null,"citation_count":73,"citer_count":53,"citers_with_citation_signal":40,"citers_with_endowment":40,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.951,"is_data_producer":true,"deposit_databanks":{"GEO":["GSE151848","GSE123507"]},"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":105024,"name":"Melissa Walker","orcid":"0000-0002-7423-9538","position":1,"is_corresponding":false},{"id":305726,"name":"Olga Ponomarova","orcid":"0000-0001-6331-9949","position":2,"is_corresponding":false},{"id":305727,"name":"Hefei Zhang","orcid":"0000-0002-5187-7166","position":3,"is_corresponding":false},{"id":305728,"name":"Xuhang Li","orcid":"0000-0001-6071-9605","position":4,"is_corresponding":false},{"id":305729,"name":"Gregory Minevich","orcid":"0000-0002-7115-4416","position":5,"is_corresponding":false},{"id":305730,"name":"Albertha J.M. Walhout","orcid":"0000-0001-5587-3608","position":6,"is_corresponding":false},{"id":305725,"name":"Gabrielle E. Giese","orcid":"0000-0002-9338-2049","position":0,"is_corresponding":true}],"reference_count":48,"raw_metadata":null,"created_at":"2026-07-18T21:07:11.345501Z","pmid":"33016879","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}