{"doi":"10.7554/elife.60191","title":"MYC regulates ribosome biogenesis and mitochondrial gene expression programs through its interaction with host cell factor–1","abstract":"The oncoprotein transcription factor MYC is a major driver of malignancy and a highly validated but challenging target for the development of anticancer therapies. Novel strategies to inhibit MYC may come from understanding the co-factors it uses to drive pro-tumorigenic gene expression programs, providing their role in MYC activity is understood. Here we interrogate how one MYC co-factor, host cell factor (HCF)-1, contributes to MYC activity in a human Burkitt lymphoma setting. We identify genes connected to mitochondrial function and ribosome biogenesis as direct MYC/HCF-1 targets and demonstrate how modulation of the MYC-HCF-1 interaction influences cell growth, metabolite profiles, global gene expression patterns, and tumor growth in vivo. This work defines HCF-1 as a critical MYC co-factor, places the MYC-HCF-1 interaction in biological context, and highlights HCF-1 as a focal point for development of novel anti-MYC therapies.","journal":"eLife","year":2021,"id":149500,"datarank":2.087322712943189,"base_score":4.663439094112067,"endowment":4.663439094112067,"self_citation_contribution":0.6995158641168101,"citation_network_contribution":1.3878068488263788,"self_endowment_contribution":0.6995158641168101,"citer_contribution":1.3878068488263788,"corpus_percentile":null,"corpus_rank":null,"citation_count":105,"citer_count":79,"citers_with_citation_signal":63,"citers_with_endowment":63,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9605,"is_data_producer":true,"deposit_databanks":{"GEO":["GSE152385","GSE126207"]},"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":463183,"name":"Jing Wang","orcid":"0000-0002-7566-1212","position":1,"is_corresponding":false},{"id":482612,"name":"Clare M. Adams","orcid":"0000-0002-9940-3795","position":2,"is_corresponding":false},{"id":289609,"name":"Gregory C. Howard","orcid":"0000-0002-8373-4573","position":3,"is_corresponding":false},{"id":373951,"name":"Simona G. Codreanu","orcid":"0000-0003-4435-812X","position":4,"is_corresponding":false},{"id":232777,"name":"Stacy D. Sherrod","orcid":"0000-0002-2346-230X","position":5,"is_corresponding":false},{"id":232772,"name":"John A. McLean","orcid":"0000-0001-8918-6419","position":6,"is_corresponding":false},{"id":482611,"name":"Lance R. Thomas","orcid":"0000-0003-0247-2741","position":7,"is_corresponding":false},{"id":289613,"name":"Shelly L. Lorey","orcid":"0000-0002-8151-8711","position":8,"is_corresponding":false},{"id":274155,"name":"Yuichi Machida","orcid":"0000-0003-1414-0568","position":9,"is_corresponding":false},{"id":289617,"name":"April M. Weissmiller","orcid":"0000-0003-4505-0530","position":10,"is_corresponding":false},{"id":280681,"name":"Christine M. Eischen","orcid":"0000-0003-4618-8996","position":11,"is_corresponding":false},{"id":555677,"name":"Qi Liu","orcid":"0000-0002-7892-5965","position":12,"is_corresponding":false},{"id":289618,"name":"William P. Tansey","orcid":"0000-0002-3900-0978","position":13,"is_corresponding":false},{"id":582426,"name":"Tessa M. Popay","orcid":"0000-0002-4694-8804","position":0,"is_corresponding":true}],"reference_count":99,"raw_metadata":null,"created_at":"2026-07-18T23:42:56.251607Z","pmid":"33416496","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}