{"doi":"10.7554/elife.59499","title":"Vascular control of the CO2/H+-dependent drive to breathe","abstract":"Respiratory chemoreceptors regulate breathing in response to changes in tissue CO 2 /H + . Blood flow is a fundamental determinant of tissue CO 2 /H + , yet little is known regarding how regulation of vascular tone in chemoreceptor regions contributes to respiratory behavior. Previously, we showed in rat that CO 2 /H + -vasoconstriction in the retrotrapezoid nucleus (RTN) supports chemoreception by a purinergic-dependent mechanism (Hawkins et al., 2017). Here, we show in mice that CO 2 /H + dilates arterioles in other chemoreceptor regions, thus demonstrating CO 2 /H + vascular reactivity in the RTN is unique. We also identify P2Y 2 receptors in RTN smooth muscle cells as the substrate responsible for this response. Specifically, pharmacological blockade or genetic deletion of P2Y 2 from smooth muscle cells blunted the ventilatory response to CO 2 , and re-expression of P2Y 2 receptors only in RTN smooth muscle cells fully rescued the CO 2 /H + chemoreflex. These results identify P2Y 2 receptors in RTN smooth muscle cells as requisite determinants of respiratory chemoreception.","journal":"eLife","year":2020,"id":97327,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":33,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9404,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":481366,"name":"Thiago S. Moreira","orcid":"0000-0002-9789-8296","position":1,"is_corresponding":false},{"id":481367,"name":"Ana C. Takakura","orcid":"0000-0001-6273-0760","position":2,"is_corresponding":false},{"id":300696,"name":"Mark T. Nelson","orcid":"0000-0002-6608-8784","position":3,"is_corresponding":false},{"id":319685,"name":"Thomas A. Longden","orcid":"0000-0002-7950-7677","position":4,"is_corresponding":false},{"id":432148,"name":"Daniel K. Mulkey","orcid":"0000-0002-7040-3927","position":5,"is_corresponding":false},{"id":481365,"name":"Colin Cleary","orcid":"0000-0003-0305-1324","position":0,"is_corresponding":true}],"reference_count":43,"raw_metadata":null,"created_at":"2026-07-18T22:35:34.520494Z","pmid":"32924935","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}