{"doi":"10.7554/elife.57680","title":"Allosteric mechanism for KCNE1 modulation of KCNQ1 potassium channel activation","abstract":"The function of the voltage-gated KCNQ1 potassium channel is regulated by co-assembly with KCNE auxiliary subunits. KCNQ1-KCNE1 channels generate the slow delayed rectifier current, I Ks , which contributes to the repolarization phase of the cardiac action potential. A three amino acid motif (F57-T58-L59, FTL) in KCNE1 is essential for slow activation of KCNQ1-KCNE1 channels. However, how this motif interacts with KCNQ1 to control its function is unknown. Combining computational modeling with electrophysiological studies, we developed structural models of the KCNQ1-KCNE1 complex that suggest how KCNE1 controls KCNQ1 activation. The FTL motif binds at a cleft between the voltage-sensing and pore domains and appears to affect the channel gate by an allosteric mechanism. Comparison with the KCNQ1-KCNE3 channel structure suggests a common transmembrane-binding mode for different KCNEs and illuminates how specific differences in the interaction of their triplet motifs determine the profound differences in KCNQ1 functional modulation by KCNE1 versus KCNE3.","journal":"eLife","year":2020,"id":93039,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":41,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.947,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":465132,"name":"Carlos G. Vanoye","orcid":"0000-0002-4935-1122","position":1,"is_corresponding":false},{"id":465133,"name":"Reshma R. Desai","orcid":"0009-0002-7006-1418","position":2,"is_corresponding":false},{"id":465134,"name":"Sneha Adusumilli","orcid":"0000-0003-0482-7147","position":3,"is_corresponding":false},{"id":465135,"name":"Kathryn R. Brewer","orcid":"0000-0001-7003-2938","position":4,"is_corresponding":false},{"id":465136,"name":"Hope Woods","orcid":"0000-0001-6615-545X","position":5,"is_corresponding":false},{"id":266531,"name":"Eli Fritz McDonald","orcid":"0000-0002-0572-330X","position":6,"is_corresponding":false},{"id":321396,"name":"Charles R. Sanders","orcid":"0000-0003-2046-2862","position":7,"is_corresponding":false},{"id":321394,"name":"Alfred L. George","orcid":"0000-0002-3993-966X","position":8,"is_corresponding":false},{"id":36757,"name":"Jens Meiler","orcid":"0000-0001-8945-193X","position":9,"is_corresponding":false},{"id":321390,"name":"Georg Kuenze","orcid":"0000-0003-1799-346X","position":0,"is_corresponding":true}],"reference_count":97,"raw_metadata":null,"created_at":"2026-07-18T22:30:54.208860Z","pmid":"33095155","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}