{"doi":"10.7554/elife.57646","title":"Thresholds for post-rebound SHIV control after CCR5 gene-edited autologous hematopoietic cell transplantation","abstract":"Autologous, CCR5 gene-edited hematopoietic stem and progenitor cell (HSPC) transplantation is a promising strategy for achieving HIV remission. However, only a fraction of HSPCs can be edited ex vivo to provide protection against infection. To project the thresholds of CCR5-edition necessary for HIV remission, we developed a mathematical model that recapitulates blood T cell reconstitution and plasma simian-HIV (SHIV) dynamics from SHIV-1157ipd3N4-infected pig-tailed macaques that underwent autologous transplantation with CCR5 gene editing. The model predicts that viral control can be obtained following analytical treatment interruption (ATI) when: (1) transplanted HSPCs are at least fivefold higher than residual endogenous HSPCs after total body irradiation and (2) the fraction of protected HSPCs in the transplant achieves a threshold (76-94%) sufficient to overcome transplantation-dependent loss of SHIV immunity. Under these conditions, if ATI is withheld until transplanted gene-modified cells engraft and reconstitute to a steady state, spontaneous viral control is projected to occur.","journal":"eLife","year":2021,"id":176003,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":21,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9548,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":326527,"name":"Elizabeth R. Duke","orcid":"0000-0002-3348-9039","position":1,"is_corresponding":false},{"id":345517,"name":"Christopher W. Peterson","orcid":"0000-0002-3215-8924","position":2,"is_corresponding":false},{"id":286355,"name":"Daniel B. Reeves","orcid":"0000-0001-5684-9538","position":3,"is_corresponding":false},{"id":254835,"name":"Bryan T. Mayer","orcid":"0000-0003-2258-5276","position":4,"is_corresponding":false},{"id":104354,"name":"Hans‐Peter Kiem","orcid":"0000-0001-5949-4947","position":5,"is_corresponding":false},{"id":246662,"name":"Joshua T. Schiffer","orcid":"0000-0002-2598-1621","position":6,"is_corresponding":false},{"id":246661,"name":"E. Fabián Cardozo-Ojeda","orcid":"0000-0001-8690-9896","position":0,"is_corresponding":true}],"reference_count":88,"raw_metadata":null,"created_at":"2026-07-18T23:47:19.591542Z","pmid":"33432929","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}