{"doi":"10.7554/elife.57578","title":"A molecular filter for the cnidarian stinging response","abstract":"All animals detect and integrate diverse environmental signals to mediate behavior. Cnidarians, including jellyfish and sea anemones, both detect and capture prey using stinging cells called nematocytes which fire a venom-covered barb via an unknown triggering mechanism. Here, we show that nematocytes from Nematostella vectensis use a specialized voltage-gated calcium channel (nCaV) to distinguish salient sensory cues and control the explosive discharge response. Adaptations in nCaV confer unusually sensitive, voltage-dependent inactivation to inhibit responses to non-prey signals, such as mechanical water turbulence. Prey-derived chemosensory signals are synaptically transmitted to acutely relieve nCaV inactivation, enabling mechanosensitive-triggered predatory attack. These findings reveal a molecular basis for the cnidarian stinging response and highlight general principles by which single proteins integrate diverse signals to elicit discrete animal behaviors.","journal":"eLife","year":2020,"id":91418,"datarank":1.195402833788219,"base_score":3.828641396489095,"endowment":3.828641396489095,"self_citation_contribution":0.5742962094733643,"citation_network_contribution":0.6211066243148546,"self_endowment_contribution":0.5742962094733643,"citer_contribution":0.6211066243148546,"corpus_percentile":null,"corpus_rank":null,"citation_count":45,"citer_count":36,"citers_with_citation_signal":27,"citers_with_endowment":27,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9534,"is_data_producer":true,"deposit_databanks":{"SRA":["PRJNA627705"]},"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":457641,"name":"Christophe Dupré","orcid":"0000-0002-5929-8492","position":1,"is_corresponding":false},{"id":270516,"name":"Lena van Giesen","orcid":"0000-0001-6370-744X","position":2,"is_corresponding":false},{"id":239478,"name":"Amy S.Y. Lee","orcid":"0000-0002-4121-0720","position":3,"is_corresponding":false},{"id":270518,"name":"Nicholas W. Bellono","orcid":"0000-0002-0829-9436","position":4,"is_corresponding":false},{"id":457640,"name":"Keiko Weir","orcid":"0000-0002-2501-9352","position":0,"is_corresponding":true}],"reference_count":67,"raw_metadata":null,"created_at":"2026-07-18T22:28:45.409789Z","pmid":"32452384","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}