{"doi":"10.7554/elife.55964","title":"Automated task training and longitudinal monitoring of mouse mesoscale cortical circuits using home cages","abstract":"We report improved automated open-source methodology for head-fixed mesoscale cortical imaging and/or behavioral training of home cage mice using Raspberry Pi-based hardware. Staged partial and probabilistic restraint allows mice to adjust to self-initiated headfixation over 3 weeks' time with ~50% participation rate. We support a cue-based behavioral licking task monitored by a capacitive touch-sensor water spout. While automatically head-fixed, we acquire spontaneous, movement-triggered, or licking task-evoked GCaMP6 cortical signals. An analysis pipeline marked both behavioral events, as well as analyzed brain fluorescence signals as they relate to spontaneous and/or task-evoked behavioral activity. Mice were trained to suppress licking and wait for cues that marked the delivery of water. Correct rewarded go-trials were associated with widespread activation of midline and lateral barrel cortex areas following a vibration cue and delayed frontal and lateral motor cortex activation. Cortical GCaMP signals predicted trial success and correlated strongly with trial-outcome dependent body movements.","journal":"eLife","year":2020,"id":63185,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":46,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9505,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":334258,"name":"Nicholas J. Michelson","orcid":"0000-0002-5991-1023","position":1,"is_corresponding":false},{"id":335656,"name":"Jamie D. Boyd","orcid":null,"position":2,"is_corresponding":false},{"id":334259,"name":"Tony Fong","orcid":"0000-0001-7810-8917","position":3,"is_corresponding":false},{"id":334260,"name":"Luis Bolaños","orcid":"0000-0002-4746-9186","position":4,"is_corresponding":false},{"id":334261,"name":"David Bierbrauer","orcid":"0000-0002-4329-8551","position":5,"is_corresponding":false},{"id":335657,"name":"Teri Siu","orcid":null,"position":6,"is_corresponding":false},{"id":334262,"name":"Matilde Balbi","orcid":"0000-0003-4590-5447","position":7,"is_corresponding":false},{"id":334263,"name":"Federico Bolaños","orcid":"0000-0002-9315-8645","position":8,"is_corresponding":false},{"id":334264,"name":"Matthieu P. Vanni","orcid":"0000-0002-5425-4167","position":9,"is_corresponding":false},{"id":335658,"name":"Jeff M. LeDue","orcid":null,"position":10,"is_corresponding":false},{"id":334257,"name":"Timothy H. Murphy","orcid":"0000-0002-0093-4490","position":0,"is_corresponding":true}],"reference_count":58,"raw_metadata":null,"created_at":"2026-07-18T21:11:00.632961Z","pmid":"32412409","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}