{"doi":"10.7554/elife.55732","title":"Novel C1q receptor-mediated signaling controls neural stem cell behavior and neurorepair","abstract":"C1q plays a key role as a recognition molecule in the immune system, driving autocatalytic complement cascade activation and acting as an opsonin. We have previously reported a non-immune role of complement C1q modulating the migration and fate of human neural stem cells (hNSC); however, the mechanism underlying these effects has not yet been identified. Here, we show for the first time that C1q acts as a functional hNSC ligand, inducing intracellular signaling to control cell behavior. Using an unbiased screening strategy, we identified five transmembrane C1q signaling/receptor candidates in hNSC (CD44, GPR62, BAI1, c-MET, and ADCY5). We further investigated the interaction between C1q and CD44 , demonstrating that CD44 mediates C1q induced hNSC signaling and chemotaxis in vitro, and hNSC migration and functional repair in vivo after spinal cord injury. These results reveal a receptor-mediated mechanism for C1q modulation of NSC behavior and show that modification of C1q receptor expression can expand the therapeutic window for hNSC transplantation.","journal":"eLife","year":2020,"id":96065,"datarank":1.3922273066778394,"base_score":3.58351893845611,"endowment":3.58351893845611,"self_citation_contribution":0.5375278407684165,"citation_network_contribution":0.8546994659094229,"self_endowment_contribution":0.5375278407684165,"citer_contribution":0.8546994659094229,"corpus_percentile":null,"corpus_rank":null,"citation_count":35,"citer_count":26,"citers_with_citation_signal":19,"citers_with_endowment":19,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9495,"is_data_producer":true,"deposit_databanks":{"GEO":["GSE103723"]},"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":476754,"name":"Katja Piltti","orcid":"0000-0002-9773-0442","position":1,"is_corresponding":false},{"id":413225,"name":"Mitra J. Hooshmand","orcid":"0000-0001-6159-6934","position":2,"is_corresponding":false},{"id":476755,"name":"Aileen A. Nava","orcid":"0000-0002-2053-6713","position":3,"is_corresponding":false},{"id":476756,"name":"Anita Lakatos","orcid":"0000-0001-8973-186X","position":4,"is_corresponding":false},{"id":477956,"name":"Brianna G Feld","orcid":null,"position":5,"is_corresponding":false},{"id":413226,"name":"Dana Creasman","orcid":"0000-0003-3994-7050","position":6,"is_corresponding":false},{"id":414378,"name":"Paul D. Gershon","orcid":"0000-0002-4904-9193","position":7,"is_corresponding":false},{"id":401608,"name":"Aileen J. Anderson","orcid":"0000-0002-8203-8891","position":8,"is_corresponding":false},{"id":476753,"name":"Francisca Benavente","orcid":"0000-0001-8245-2673","position":0,"is_corresponding":true}],"reference_count":78,"raw_metadata":null,"created_at":"2026-07-18T22:34:34.781847Z","pmid":"32894219","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}