{"doi":"10.7554/elife.52896","title":"Recruitment of mRNAs to P granules by condensation with intrinsically-disordered proteins","abstract":"RNA granules are protein/RNA condensates. How specific mRNAs are recruited to cytoplasmic RNA granules is not known. Here, we characterize the transcriptome and assembly of P granules, RNA granules in the C. elegans germ plasm. We find that P granules recruit mRNAs by condensation with the disordered protein MEG-3. MEG-3 traps mRNAs into non-dynamic condensates in vitro and binds to ~500 mRNAs in vivo in a sequence-independent manner that favors embryonic mRNAs with low ribosome coverage. Translational stress causes additional mRNAs to localize to P granules and translational activation correlates with P granule exit for two mRNAs coding for germ cell fate regulators. Localization to P granules is not required for translational repression but is required to enrich mRNAs in the germ lineage for robust germline development. Our observations reveal similarities between P granules and stress granules and identify intrinsically-disordered proteins as drivers of RNA condensation during P granule assembly.","journal":"eLife","year":2020,"id":52268,"datarank":3.605308054110526,"base_score":4.927253685157205,"endowment":4.927253685157205,"self_citation_contribution":0.7390880527735809,"citation_network_contribution":2.866220001336945,"self_endowment_contribution":0.7390880527735809,"citer_contribution":2.866220001336945,"corpus_percentile":null,"corpus_rank":null,"citation_count":137,"citer_count":100,"citers_with_citation_signal":100,"citers_with_endowment":100,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9612,"is_data_producer":true,"deposit_databanks":{"GEO":["GSE139878","GSE139880","GSE139879","GSE100652"]},"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":244823,"name":"Andrea Putnam","orcid":"0000-0001-7985-142X","position":1,"is_corresponding":false},{"id":263698,"name":"Tu Lu","orcid":"0000-0002-5697-300X","position":2,"is_corresponding":false},{"id":265375,"name":"ShuaiXin He","orcid":null,"position":3,"is_corresponding":false},{"id":217761,"name":"John Paul T. Ouyang","orcid":"0000-0003-2030-432X","position":4,"is_corresponding":false},{"id":263699,"name":"Géraldine Seydoux","orcid":"0000-0001-8257-0493","position":5,"is_corresponding":false},{"id":265374,"name":"Chih-Yung S Lee","orcid":null,"position":0,"is_corresponding":true}],"reference_count":82,"raw_metadata":null,"created_at":"2026-07-18T20:42:26.843314Z","pmid":"31975687","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}