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We suggest that it is important not to treat brain aging as a single homogeneous process, and that modelling of distinct patterns of structural and functional change will reveal more biologically meaningful markers of brain aging in health and disease.</jats:p>","journal":"eLife","year":2020,"id":628386,"datarank":0.811075765719018,"base_score":5.407171771460119,"endowment":5.407171771460119,"self_citation_contribution":0.811075765719018,"citation_network_contribution":0.0,"self_endowment_contribution":0.811075765719018,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":222,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":2,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1626925,"name":"Lloyd T Elliott","orcid":null,"position":1,"is_corresponding":false},{"id":12942,"name":"Fidel Alfaro-Almagro","orcid":null,"position":2,"is_corresponding":false},{"id":766584,"name":"Paul McCarthy","orcid":"0000-0002-4896-8374","position":3,"is_corresponding":false},{"id":1626926,"name":"Thomas E Nichols","orcid":null,"position":4,"is_corresponding":false},{"id":12952,"name":"Gwenaëlle Douaud","orcid":"0000-0003-1981-391X","position":5,"is_corresponding":false},{"id":12941,"name":"Karla L. 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The modes represent different aspects of brain aging, showing distinct patterns of functional and structural brain change, and distinct patterns of association with genetics, lifestyle, cognition, physical measures and disease. While conventional brain-age modelling found no genetic associations, 34 modes had genetic associations. We suggest that it is important not to treat brain aging as a single homogeneous process, and that modelling of distinct patterns of structural and functional change will reveal more biologically meaningful markers of brain aging in health and disease.</jats:p>","is_dataset_classified":null,"base_score":0.0,"endowment":0.0,"datacite_reuse_total":2,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"32134384","pmcid":"PMC7162660","openalex_id":null,"authors":[],"funders":[{"funder_name":"Wellcome","grant_id":"203139/Z/16/Z","title":null},{"funder_name":"Wellcome","grant_id":"098369/Z/12/Z","title":null},{"funder_name":"Wellcome","grant_id":"215573/Z/19/Z","title":null},{"funder_name":"Wellcome","grant_id":"202788/Z/16/Z","title":null},{"funder_name":"Medical Research Council","grant_id":"MR/K006673/1","title":"Structural and Functional Connectivity of the Human Basal Ganglia in Health and Disease using High Resolution MRI at 7T"},{"funder_name":"Wellcome Trust","grant_id":"100309/A/12/Z","title":null},{"funder_name":"Medical Research Council","grant_id":"MC_QA137853","title":null},{"funder_name":"Medical Research Council","grant_id":"MC_PC_17228","title":null},{"funder_name":"Wellcome Trust","grant_id":"098369","title":"Integrated multimodal brain imaging for neuroscience research and clinical practice."},{"funder_name":"Wellcome Trust","grant_id":"unidentified","title":"unidentified"},{"funder_name":"Wellcome Trust","grant_id":"202788","title":"Linking MRI and microscopy for multi-scale neuroscience: Mechanisms, diagnostics and anatomy"},{"funder_name":"Wellcome Trust","grant_id":"98369","title":"Integrated multimodal brain imaging for neuroscience research and clinical practice."},{"funder_name":"Wellcome Trust","grant_id":"203139","title":"Wellcome Centre for Integrative Neuroimaging"},{"funder_name":"Wellcome Trust","grant_id":"215573","title":"Integrative imaging of brain structure and function in populations and individuals"},{"funder_name":"Wellcome Trust","grant_id":"","title":null}],"total_grants":15,"fwci":null,"citation_percentile":null,"influential_citations":0,"citation_trend":[],"oa_status":"gold","license":"cc-by","oa_locations":[{"url":"https://doi.org/10.7554/elife.52677","host_type":"publisher"},{"url":"https://cdn.elifesciences.org/articles/52677/elife-52677-v2.pdf","host_type":"publisher"},{"url":"https://cdn.elifesciences.org/articles/52677/elife-52677-v2.xml","host_type":"publisher"},{"url":"https://elifesciences.org/articles/52677","host_type":"publisher"},{"url":"https://doaj.org/article/aec871cafe71411183c2a93996f14086","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7162660","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC7162660","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC7162660?pdf=render","host_type":"Europe_PMC"},{"url":"https://doi.org/10.1101/802686","host_type":""},{"url":"https://www.biorxiv.org/content/biorxiv/early/2020/01/18/802686.full.pdf","host_type":""},{"url":"https://pubmed.ncbi.nlm.nih.gov/32134384","host_type":""},{"url":"http://dx.doi.org/10.7554/eLife.52677","host_type":""},{"url":"https://dx.doi.org/10.7554/elife.52677","host_type":""},{"url":"https://dx.doi.org/10.1101/802686","host_type":""},{"url":"https://ora.ox.ac.uk/objects/uuid:322b7a9e-017b-46a2-9047-737a577f08ca","host_type":""},{"url":"http://dx.doi.org/10.1101/802686","host_type":""}],"fields_of_study":["0301 basic medicine","03 medical and health sciences","0302 clinical medicine"],"mesh_terms":["Brain","Humans","Magnetic Resonance Imaging","Aging","Adult","Aged","Aged, 80 and over","Middle Aged","Biological Specimen Banks","Female","Male","United Kingdom"],"keywords":["Human","Neuroscience","Brain imaging","brain aging","Uk Biobank","Adult","Male","Aging","QH301-705.5","Science","Humans","Biology (General)","Aged","Biological Specimen Banks","Aged, 80 and over","Q","R","Brain","Middle Aged","Magnetic Resonance Imaging","United Kingdom","Medicine","Female"],"sdg_mappings":[{"sdg_number":3,"sdg_label":"3. 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