{"doi":"10.7554/elife.52551","title":"Identification of scavenger receptor B1 as the airway microfold cell receptor for Mycobacterium tuberculosis","abstract":"(Mtb) can enter the body through multiple routes, including via specialized transcytotic cells called microfold cells (M cell). However, the mechanistic basis for M cell entry remains undefined. Here, we show that M cell transcytosis depends on the Mtb Type VII secretion machine and its major virulence factor EsxA. We identify scavenger receptor B1 (SR-B1) as an EsxA receptor on airway M cells. SR-B1 is required for Mtb binding to and translocation across M cells in mouse and human tissue. Together, our data demonstrate a previously undescribed role for Mtb EsxA in mucosal invasion and identify SR-B1 as the airway M cell receptor for Mtb.","journal":"eLife","year":2020,"id":94650,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":37,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9622,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":472345,"name":"Vidhya R. Nair","orcid":null,"position":1,"is_corresponding":false},{"id":257955,"name":"Cody R. Ruhl","orcid":"0000-0001-9440-1013","position":2,"is_corresponding":false},{"id":471389,"name":"Samuel Álvarez-Arguedas","orcid":"0000-0002-5748-6078","position":3,"is_corresponding":false},{"id":472346,"name":"Jorge L Galvan Rendiz","orcid":null,"position":4,"is_corresponding":false},{"id":257958,"name":"Luis H. Franco","orcid":"0000-0002-8143-1384","position":5,"is_corresponding":false},{"id":240352,"name":"Linzhang Huang","orcid":"0000-0002-9092-2855","position":6,"is_corresponding":false},{"id":240353,"name":"Philip W. Shaul","orcid":"0000-0003-1157-4002","position":7,"is_corresponding":false},{"id":255300,"name":"Jiwoong Kim","orcid":"0000-0003-0220-9329","position":8,"is_corresponding":false},{"id":326811,"name":"Yang Xie","orcid":"0000-0001-9456-1762","position":9,"is_corresponding":false},{"id":460836,"name":"Ron B. Mitchell","orcid":"0000-0001-7890-0541","position":10,"is_corresponding":false},{"id":257967,"name":"Michael U. Shiloh","orcid":"0000-0003-4329-2253","position":11,"is_corresponding":false},{"id":260939,"name":"Haaris Khan","orcid":null,"position":0,"is_corresponding":true}],"reference_count":73,"raw_metadata":null,"created_at":"2026-07-18T22:33:00.770265Z","pmid":"32134383","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}