{"doi":"10.7554/elife.52535","title":"Tuberculosis-associated IFN-I induces Siglec-1 on tunneling nanotubes and favors HIV-1 spread in macrophages","abstract":"(Mtb) worsens HIV-1 pathogenesis remain scarce. We showed that HIV-1 infection is exacerbated in macrophages exposed to TB-associated microenvironments due to tunneling nanotube (TNT) formation. To identify molecular factors associated with TNT function, we performed a transcriptomic analysis in these macrophages, and revealed the up-regulation of Siglec-1 receptor. Siglec-1 expression depends on Mtb-induced production of type I interferon (IFN-I). In co-infected non-human primates, Siglec-1 is highly expressed by alveolar macrophages, whose abundance correlates with pathology and activation of IFN-I/STAT1 pathway. Siglec-1 localizes mainly on microtubule-containing TNT that are long and carry HIV-1 cargo. Siglec-1 depletion decreases TNT length, diminishes HIV-1 capture and cell-to-cell transfer, and abrogates the exacerbation of HIV-1 infection induced by Mtb. Altogether, we uncover a deleterious role for Siglec-1 in TB-HIV-1 co-infection and open new avenues to understand TNT biology.","journal":"eLife","year":2020,"id":59368,"datarank":0.6329261557764161,"base_score":4.219507705176107,"endowment":4.219507705176107,"self_citation_contribution":0.6329261557764161,"citation_network_contribution":0.0,"self_endowment_contribution":0.6329261557764161,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":67,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9529,"is_data_producer":true,"deposit_databanks":{"GEO":["GSE139511"]},"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":313213,"name":"Shanti Souriant","orcid":null,"position":1,"is_corresponding":false},{"id":312194,"name":"Luciana Balboa","orcid":"0000-0001-7045-3572","position":2,"is_corresponding":false},{"id":312195,"name":"Thien‐Phong Vu Manh","orcid":"0000-0002-0294-342X","position":3,"is_corresponding":false},{"id":313214,"name":"Karine Pingris","orcid":null,"position":4,"is_corresponding":false},{"id":312196,"name":"Stella Rousset","orcid":"0000-0003-1564-5197","position":5,"is_corresponding":false},{"id":312197,"name":"Céline Cougoule","orcid":"0000-0002-6795-5448","position":6,"is_corresponding":false},{"id":312198,"name":"Yoann Rombouts","orcid":"0000-0003-4482-2199","position":7,"is_corresponding":false},{"id":312199,"name":"Renaud Poincloux","orcid":"0000-0003-2884-1744","position":8,"is_corresponding":false},{"id":312200,"name":"Myriam Ben Neji","orcid":"0009-0008-7414-349X","position":9,"is_corresponding":false},{"id":259614,"name":"Carolina Allers","orcid":"0000-0001-8576-770X","position":10,"is_corresponding":false},{"id":245291,"name":"Deepak Kaushal","orcid":"0000-0003-3521-1257","position":11,"is_corresponding":false},{"id":312201,"name":"Marcelo J. Kuroda","orcid":"0000-0003-3736-9429","position":12,"is_corresponding":false},{"id":312202,"name":"Susana Benet","orcid":"0000-0002-2219-8826","position":13,"is_corresponding":false},{"id":31314,"name":"Javier Martínez‐Picado","orcid":"0000-0002-4916-2129","position":14,"is_corresponding":false},{"id":312203,"name":"Nuria Izquierdo‐Useros","orcid":"0000-0002-1039-1821","position":15,"is_corresponding":false},{"id":312204,"name":"Marı́a del Carmen Sasiain","orcid":"0000-0001-5616-7270","position":16,"is_corresponding":false},{"id":312205,"name":"Isabelle Maridonneau‐Parini","orcid":"0000-0003-0189-0976","position":17,"is_corresponding":false},{"id":312206,"name":"Olivier Neyrolles","orcid":"0000-0003-0047-5885","position":18,"is_corresponding":false},{"id":312207,"name":"Christel Vérollet","orcid":"0000-0002-1079-9085","position":19,"is_corresponding":false},{"id":312208,"name":"Geanncarlo Lugo‐Villarino","orcid":"0000-0003-4620-8491","position":20,"is_corresponding":false},{"id":312193,"name":"Maeva Dupont","orcid":"0000-0002-0514-4447","position":0,"is_corresponding":true}],"reference_count":71,"raw_metadata":null,"created_at":"2026-07-18T21:07:59.189921Z","pmid":"32223897","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}