{"doi":"10.7554/elife.52212","title":"MS-275, a class 1 histone deacetylase inhibitor augments glucagon-like peptide-1 receptor agonism to improve glycemic control and reduce obesity in diet-induced obese mice","abstract":"Given its glycemic efficacy and ability to reduce the body weight, glucagon-like peptide 1 receptor (GLP-1R) agonism has emerged as a preferred treatment for diabetes associated with obesity. We here report that a small-molecule Class 1 histone deacetylase (HDAC) inhibitor Entinostat (MS-275) enhances GLP-1R agonism to potentiate glucose-stimulated insulin secretion and decrease body weight in diet-induced obese (DIO) mice. MS-275 is not an agonist or allosteric activator of GLP-1R but enhances the sustained receptor-mediated signaling through the modulation of the expression of proteins involved in the signaling pathway. MS-275 and liraglutide combined therapy improved fasting glycemia upon short-term treatment and a chronic administration causes a reduction of obesity in DIO mice. Overall, our results emphasize the therapeutic potential of MS-275 as an adjunct to GLP-1R therapy in the treatment of diabetes and obesity.","journal":"eLife","year":2020,"id":79141,"datarank":0.8184065064657517,"base_score":2.8903717578961645,"endowment":2.8903717578961645,"self_citation_contribution":0.4335557636844247,"citation_network_contribution":0.38485074278132697,"self_endowment_contribution":0.4335557636844247,"citer_contribution":0.38485074278132697,"corpus_percentile":null,"corpus_rank":null,"citation_count":17,"citer_count":15,"citers_with_citation_signal":12,"citers_with_endowment":12,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9529,"is_data_producer":true,"deposit_databanks":{"GEO":["GSE139147"]},"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":411470,"name":"Shravan Babu Girada","orcid":"0000-0003-4632-0993","position":1,"is_corresponding":false},{"id":412621,"name":"Aramita Ray","orcid":null,"position":2,"is_corresponding":false},{"id":411471,"name":"Abhishek Gupta","orcid":"0000-0002-3932-2512","position":3,"is_corresponding":false},{"id":411472,"name":"Srinivas Oruganti","orcid":"0000-0001-7111-904X","position":4,"is_corresponding":false},{"id":411473,"name":"Phanithi Prakash Babu","orcid":"0000-0002-1528-8575","position":5,"is_corresponding":false},{"id":412622,"name":"Rahul SR Rayalla","orcid":null,"position":6,"is_corresponding":false},{"id":412623,"name":"Shashi Vardhan Kalivendi","orcid":null,"position":7,"is_corresponding":false},{"id":411474,"name":"Ahamed Ibrahim","orcid":"0000-0002-9365-2563","position":8,"is_corresponding":false},{"id":291367,"name":"Vishwajeet Puri","orcid":"0000-0003-1303-8967","position":9,"is_corresponding":false},{"id":412624,"name":"Venkateswar Adalla","orcid":null,"position":10,"is_corresponding":false},{"id":411475,"name":"Madhumohan Rao Katika","orcid":"0000-0002-7264-5137","position":11,"is_corresponding":false},{"id":63185,"name":"Richard D. DiMarchi","orcid":"0000-0003-0220-4085","position":12,"is_corresponding":false},{"id":411476,"name":"Prasenjit Mitra","orcid":"0000-0001-6494-4623","position":13,"is_corresponding":false},{"id":411469,"name":"Shilpak Bele","orcid":"0000-0002-8507-1187","position":0,"is_corresponding":true}],"reference_count":67,"raw_metadata":null,"created_at":"2026-07-18T21:50:33.748601Z","pmid":"33349332","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}