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We pooled diverse transcriptionally barcoded gene deletion mutants in 11 different environmental conditions and determined their expression state by sequencing 38,285 individual cells. We benchmarked a framework for learning gene regulatory networks from scRNAseq data that incorporates multitask learning and constructed a global gene regulatory network comprising 12,228 interactions.</jats:p>","journal":"eLife","year":2020,"id":598441,"datarank":0.7535820781269416,"base_score":5.0238805208462765,"endowment":5.0238805208462765,"self_citation_contribution":0.7535820781269416,"citation_network_contribution":0.0,"self_endowment_contribution":0.7535820781269416,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":151,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":807589,"name":"Dayanne M Castro","orcid":null,"position":1,"is_corresponding":false},{"id":559184,"name":"Giuseppe-Antonio Saldi","orcid":"0000-0002-9994-7354","position":2,"is_corresponding":false},{"id":476,"name":"Richard Bonneau","orcid":"0000-0003-4354-7906","position":3,"is_corresponding":false},{"id":332260,"name":"David Gresham","orcid":"0000-0002-4028-0364","position":4,"is_corresponding":false},{"id":559183,"name":"Christopher A. 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To leverage these advantages, we developed a method for scRNAseq in budding yeast (Saccharomyces cerevisiae). We pooled diverse transcriptionally barcoded gene deletion mutants in 11 different environmental conditions and determined their expression state by sequencing 38,285 individual cells. 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