{"doi":"10.7554/elife.51102","title":"A novel role for lipoxin A4 in driving a lymph node–eye axis that controls autoimmunity to the neuroretina","abstract":"The eicosanoid lipoxin A4 (LXA4) has emerging roles in lymphocyte-driven diseases. We identified reduced LXA4 levels in posterior segment uveitis patients and investigated the role of LXA4 in the pathogenesis of experimental autoimmune uveitis (EAU). Immunization for EAU with a retinal self-antigen caused selective downregulation of LXA4 in lymph nodes draining the site of immunization, while at the same time amplifying LXA4 in the inflamed target tissue. T cell effector function, migration and glycolytic responses were amplified in LXA4-deficient mice, which correlated with more severe pathology, whereas LXA4 treatment attenuated disease. In vivo deletion or supplementation of LXA4 identified modulation of CC-chemokine receptor 7 (CCR7) and sphingosine 1- phosphate receptor-1 (S1PR1) expression and glucose metabolism in CD4+ T cells as potential mechanisms for LXA4 regulation of T cell effector function and trafficking. Our results demonstrate the intrinsic lymph node LXA4 pathway as a significant checkpoint in the development and severity of adaptive immunity.","journal":"eLife","year":2020,"id":85826,"datarank":0.7049286753998745,"base_score":2.8903717578961645,"endowment":2.8903717578961645,"self_citation_contribution":0.4335557636844247,"citation_network_contribution":0.27137291171544975,"self_endowment_contribution":0.4335557636844247,"citer_contribution":0.27137291171544975,"corpus_percentile":null,"corpus_rank":null,"citation_count":17,"citer_count":12,"citers_with_citation_signal":11,"citers_with_endowment":11,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9499,"is_data_producer":true,"deposit_databanks":{"ClinicalTrials.gov":["NCT02656381"]},"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":251051,"name":"Mary J. Mattapallil","orcid":"0000-0003-0615-7343","position":1,"is_corresponding":false},{"id":251059,"name":"Reiko Horai","orcid":"0000-0001-9382-4444","position":2,"is_corresponding":false},{"id":251056,"name":"Yingyos Jittayasothorn","orcid":"0000-0001-6977-2728","position":3,"is_corresponding":false},{"id":438163,"name":"Arnav P. Modi","orcid":"0000-0002-9571-4967","position":4,"is_corresponding":false},{"id":436281,"name":"H. Nida Sen","orcid":"0000-0002-5919-0377","position":5,"is_corresponding":false},{"id":438164,"name":"Karsten Gronert","orcid":"0000-0002-5329-7907","position":6,"is_corresponding":false},{"id":251060,"name":"Rachel R Caspi","orcid":"0000-0002-7140-7671","position":7,"is_corresponding":false},{"id":438162,"name":"Jessica Wei","orcid":"0000-0002-7329-2812","position":0,"is_corresponding":true}],"reference_count":43,"raw_metadata":null,"created_at":"2026-07-18T21:58:16.217017Z","pmid":"32118582","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}