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Thus, gbM likely originates from the simultaneous targeting of loci by pathways that promote euchromatin and heterochromatin, which primes genes for the formation of stably inherited epimutations in the form of CG DNA methylation.</jats:p>","journal":"eLife","year":2019,"id":649710,"datarank":0.6610078870896381,"base_score":4.406719247264253,"endowment":4.406719247264253,"self_citation_contribution":0.6610078870896381,"citation_network_contribution":0.0,"self_endowment_contribution":0.6610078870896381,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":81,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":12,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":292296,"name":"Yinwen Zhang","orcid":"0000-0001-8776-6823","position":1,"is_corresponding":false},{"id":292298,"name":"Lexiang Ji","orcid":"0000-0003-2670-8413","position":2,"is_corresponding":false},{"id":1693796,"name":"Xiuling Shi","orcid":null,"position":3,"is_corresponding":false},{"id":258647,"name":"Rashmi R. 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The mechanisms that establish gbM are unclear, yet flowering plant species naturally without gbM lack the DNA methyltransferase, CMT3, which maintains CHG (H = A, C, or T) and not CG methylation at constitutive heterochromatin. Here, we identify the mechanistic basis for gbM establishment by expressing CMT3 in a species naturally lacking CMT3. CMT3 expression reconstituted gbM through a progression of de novo CHG methylation on expressed genes, followed by the accumulation of CG methylation that could be inherited even following loss of the CMT3 transgene. Thus, gbM likely originates from the simultaneous targeting of loci by pathways that promote euchromatin and heterochromatin, which primes genes for the formation of stably inherited epimutations in the form of CG DNA methylation.</jats:p>","is_dataset_classified":null,"base_score":4.406719247264253,"endowment":4.406719247264253,"datacite_reuse_total":12,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"31356150","pmcid":"PMC6663294","openalex_id":"https://openalex.org/W2965777662","authors":[],"funders":[{"funder_name":"Pew Charitable Trusts","grant_id":"Pew Scholar in the Biomedical Sciences","title":null},{"funder_name":"National Science Foundation","grant_id":"NSF NPGI Postdoctoral Fellowship IOS-1811694","title":null},{"funder_name":"German Excellence Initiative and the European Seventh Framework Programme","grant_id":"Grant agreement no. 291763","title":null},{"funder_name":"National Science Foundation","grant_id":"NSF MCB-1856143","title":null},{"funder_name":"National Science Foundation","grant_id":"1811694","title":"Epigenomic Consequences of Increased Heterochromatin Load in Maize"},{"funder_name":"European Commission","grant_id":"291763","title":"TUM-IAS Fellowships for the cooperative development of high risk new fields in technology and science"},{"funder_name":"National Science Foundation","grant_id":"1856143","title":"Investigating the mechanistic origins, maintenance and functions of gene body DNA methylation in plants"}],"total_grants":7,"fwci":16.3978,"citation_percentile":0.99120873,"influential_citations":0,"citation_trend":[{"year":2019,"count":6},{"year":2020,"count":19},{"year":2021,"count":15},{"year":2022,"count":11},{"year":2023,"count":12},{"year":2024,"count":9},{"year":2025,"count":5},{"year":2026,"count":4}],"oa_status":"gold","license":"cc-by","oa_locations":[{"url":"https://doi.org/10.7554/elife.47891","host_type":"journal"},{"url":"https://doi.org/10.7554/elife.47891","host_type":"publisher"},{"url":"https://cdn.elifesciences.org/articles/47891/elife-47891-v1.pdf","host_type":"publisher"},{"url":"https://cdn.elifesciences.org/articles/47891/elife-47891-v1.xml","host_type":"publisher"},{"url":"https://elifesciences.org/articles/47891","host_type":"publisher"},{"url":"https://pubmed.ncbi.nlm.nih.gov/31356150","host_type":"repository"},{"url":"https://doaj.org/article/40aca837939346de9e740d3baac1a883","host_type":"repository"},{"url":"http://mediatum.ub.tum.de/node?id=1546670","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6663294","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC6663294","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC6663294?pdf=render","host_type":"Europe_PMC"},{"url":"http://dx.doi.org/10.7554/eLife.47891","host_type":""},{"url":"https://dx.doi.org/10.7554/elife.47891","host_type":""}],"fields_of_study":["Plant Molecular Biology Research","Plant Gene Expression Analysis","Plant tissue culture and regeneration","0301 basic medicine","03 medical and health sciences","Brassicaceae","DNA (Cytosine-5-)-Methyltransferases","DNA Methylation","Mutation","Plants, Genetically Modified","Recombinant Proteins"],"mesh_terms":["DNA (Cytosine-5-)-Methyltransferases","Mutation","Recombinant Proteins","DNA Methylation","Brassicaceae","Plants, Genetically Modified"],"keywords":["DNA methylation","Euchromatin","Heterochromatin","Methylation","Biology","Genetics","Epigenetics","Gene","Methyltransferase","DNA methyltransferase","Epigenomics","DNA","Chromatin","Cell biology","Molecular biology","Gene expression","chromosomes","Plant Biology","Epimutation","A. thaliana","Eutrema Salsugineum","Gene Body Methylation","QH301-705.5","Science","Q","R","Chromosomes and Gene Expression","Plants, Genetically Modified","Recombinant Proteins","Brassicaceae","Mutation","Medicine","DNA (Cytosine-5-)-Methyltransferases","Biology (General)"],"sdg_mappings":[{"sdg_number":15,"sdg_label":"15. 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