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The imaging protocol and analysis pipeline are outlined, along with preliminary analyses of the first 7,157 subjects (more than twice as many as the largest previous ASL study). Significant associations with a range of factors are found, including those relating to the heart and blood vessels, alcohol consumption, cognitive tasks, white matter lesions and health information, such as hearing loss and depression. ASL is shown to be more sensitive to many of these factors than other imaging modalities, complementing the existing range of structural and functional measures available in the protocol. This resource is available to researchers worldwide, which we hope will facilitate new insights into healthy brain function and pathophysiology, and potentially allow the identification of early markers of disease as long-term health outcomes accumulate.</jats:p>","journal":null,"year":null,"id":608980,"datarank":0.10397207708399181,"base_score":0.6931471805599453,"endowment":0.6931471805599453,"self_citation_contribution":0.10397207708399181,"citation_network_contribution":0.0,"self_endowment_contribution":0.10397207708399181,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":1,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1215703,"name":"Xinyi Xu","orcid":"0000-0003-4703-4040","position":1,"is_corresponding":false},{"id":762342,"name":"Martin Craig","orcid":"0000-0003-4956-4512","position":2,"is_corresponding":false},{"id":12960,"name":"Fidel Alfaro‐Almagro","orcid":"0000-0002-9133-5951","position":3,"is_corresponding":false},{"id":12944,"name":"David L. 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Here, we describe the inclusion of ASL in the repeat-imaging component of the UK Biobank imaging study, a prospective epidemiological study that has acquired 100,000 first-scan datasets and aims to accumulate over 60,000 repeat-scan datasets in predominantly healthy participants, along with rich information about lifestyle factors, genetics and long-term health outcomes. The imaging protocol and analysis pipeline are outlined, along with preliminary analyses of the first 7,157 subjects (more than twice as many as the largest previous ASL study). Significant associations with a range of factors are found, including those relating to the heart and blood vessels, alcohol consumption, cognitive tasks, white matter lesions and health information, such as hearing loss and depression. ASL is shown to be more sensitive to many of these factors than other imaging modalities, complementing the existing range of structural and functional measures available in the protocol. 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