{"doi":"10.7554/elife.105649.1.sa2","title":"Reviewer #1 (Public review): Type-I nNOS neurons orchestrate cortical neural activity and vasomotion","abstract":"It is unknown how the brain orchestrates coordination of global neural and vascular dynamics. We sought to uncover the role of a sparse but unusual population of genetically-distinct interneurons known as type-I nNOS neurons, using a novel pharmacological strategic to unilaterally ablate these neurons from the somatosensory cortex of mice. Region-specific ablation produced changes in both neural activity and vascular dynamics, decreased power in the delta-band of the local field potential, reduced sustained vascular responses to prolonged sensory stimulation, and abolished the post-stimulus undershoot in cerebral blood volume. Coherence between the left and right somatosensory cortex gamma-band power envelope and blood volume at ultra-low frequencies was decreased, suggesting type-1 nNOS neurons integrate long-range coordination of brain signals. Lastly, we observed decreases in the amplitude of resting-state blood volume oscillations and decreased vasomotion following the ablation of type-I nNOS neurons. This demonstrates that a small population of nNOS-positive neurons are indispensable for regulating both neural and vascular dynamics in the whole brain and implicates disruption of these neurons in diseases ranging from neurodegeneration to sleep disturbances.","journal":null,"year":2025,"id":563974,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9525,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1467158,"name":"Dakota F Brockway","orcid":null,"position":1,"is_corresponding":false},{"id":1355058,"name":"Md Shakhawat Hossain","orcid":"0000-0003-0713-0740","position":2,"is_corresponding":false},{"id":1467159,"name":"Keith R Griffith","orcid":null,"position":3,"is_corresponding":false},{"id":1467160,"name":"Denver I Greenawalt","orcid":null,"position":4,"is_corresponding":false},{"id":571363,"name":"Qingguang Zhang","orcid":"0000-0003-4500-813X","position":5,"is_corresponding":false},{"id":1467161,"name":"Kyle W Gheres","orcid":null,"position":6,"is_corresponding":false},{"id":1467162,"name":"Nicole A Crowley","orcid":null,"position":7,"is_corresponding":false},{"id":1467163,"name":"Patrick J Drew","orcid":null,"position":8,"is_corresponding":false},{"id":1467157,"name":"Kevin L Turner","orcid":null,"position":0,"is_corresponding":true}],"reference_count":0,"raw_metadata":null,"created_at":"2026-07-19T02:56:17.117043Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}