{"doi":"10.7554/elife.105277.1.sa4","title":"Author response: Layilin Regulates Treg Motility and Suppressive Capacity in Skin","abstract":"Regulatory T cells (Tregs) are essential for maintaining immune tolerance in both lymphoid and non-lymphoid tissues. We discovered that layilin, a C-type lectin receptor, is predominantly expressed on Tregs in skin. Layilin was highly expressed on a subset of clonally expanded ‘effector’ Tregs in both healthy and psoriatic skin. Layilin expressing Tregs exhibited a transcriptional profile indicative of enhanced adhesion. Deletion of layilin in Tregs in vivo resulted in significantly attenuated skin inflammation. Mechanistically, layilin enhanced Treg adhesion via modulation of LFA-1, resulting in distinct cytoskeletal alterations consistent with enhanced focal adhesion and lamellipodia formation. Taken together, we define layilin as a critical regulator of Treg suppressive capacity through modulating motility and adhesion in a non-lymphoid tissue.","journal":null,"year":2025,"id":569488,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9522,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":261073,"name":"Sean Clancy","orcid":null,"position":1,"is_corresponding":false},{"id":1454229,"name":"Courtney Macon","orcid":null,"position":2,"is_corresponding":false},{"id":93550,"name":"J. W. F. Valle","orcid":"0000-0002-1881-5094","position":3,"is_corresponding":false},{"id":258594,"name":"Mariela Pauli","orcid":"0000-0002-9180-4789","position":4,"is_corresponding":false},{"id":1454230,"name":"Hong-An Troung","orcid":null,"position":5,"is_corresponding":false},{"id":254161,"name":"Jarish N. Cohen","orcid":"0000-0002-6043-2177","position":6,"is_corresponding":false},{"id":638155,"name":"Maxime Kinet","orcid":"0000-0002-9026-8777","position":7,"is_corresponding":false},{"id":249272,"name":"Margaret M. Lowe","orcid":"0000-0002-5623-7707","position":8,"is_corresponding":false},{"id":108494,"name":"Samuel J. Lord","orcid":"0000-0002-2785-989X","position":9,"is_corresponding":false},{"id":311454,"name":"Kristen Skruber","orcid":"0000-0003-2054-6652","position":10,"is_corresponding":false},{"id":258598,"name":"Hobart W. Harris","orcid":"0000-0002-1196-1558","position":11,"is_corresponding":false},{"id":258599,"name":"Esther Kim","orcid":"0000-0001-5652-4135","position":12,"is_corresponding":false},{"id":94248,"name":"Isaac Neuhaus","orcid":"0000-0002-0919-1291","position":13,"is_corresponding":false},{"id":1453740,"name":"Karin Reif","orcid":"0000-0001-5490-8389","position":14,"is_corresponding":false},{"id":1453741,"name":"Ali A. Zarrin","orcid":"0000-0002-9743-8716","position":15,"is_corresponding":false},{"id":106699,"name":"R. Dyche Mullins","orcid":"0000-0002-0871-5479","position":16,"is_corresponding":false},{"id":249276,"name":"Michael Rosenblum","orcid":"0000-0001-7411-4172","position":17,"is_corresponding":false},{"id":310601,"name":"Victoire Gouirand","orcid":"0000-0002-2666-0061","position":0,"is_corresponding":true}],"reference_count":0,"raw_metadata":null,"created_at":"2026-07-19T02:56:59.652443Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}