{"doi":"10.7554/elife.104913","title":"Secretory leukocyte protease inhibitor influences periarticular joint inflammation in Borrelia burgdorferi-infected mice","abstract":"Lyme disease, caused by Borrelia burgdorferi , is the most common tick-borne infection in the United States. Arthritis is a major clinical manifestation of infection, and synovial tissue damage has been attributed to the excessive pro-inflammatory responses. The secretory leukocyte protease inhibitor (SLPI) promotes tissue repair and exerts anti-inflammatory effects. The role of SLPI in the development of Lyme arthritis in C57BL/6 mice, which can be infected with B. burgdorferi but only develop mild joint inflammation, was therefore examined. Slpi -deficient C57BL/6 mice challenged with B. burgdorferi had a higher infection load in the tibiotarsal joints and marked periarticular swelling compared to infected wild-type control mice. The ankle joint tissues of B. burgdorferi- infected Slpi -deficient mice contained significantly higher percentages of infiltrating neutrophils and macrophages. B. burgdorferi -infected Slpi -deficient mice also exhibited elevated serum levels of IL-6, neutrophil elastase, and MMP-8. Moreover, using a recently developed BASEHIT ( BA cterial S election to E lucidate H ost-microbe I nteractions in high T hroughput) library, we found that SLPI directly interacts with B. burgdorferi . These data demonstrate the importance of SLPI in suppressing periarticular joint inflammation in Lyme disease.","journal":"eLife","year":2025,"id":555071,"datarank":0.24141568686511508,"base_score":1.6094379124341003,"endowment":1.6094379124341003,"self_citation_contribution":0.24141568686511508,"citation_network_contribution":0.0,"self_endowment_contribution":0.24141568686511508,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":4,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9562,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":761838,"name":"Xiaotian Tang","orcid":"0000-0002-0171-9354","position":1,"is_corresponding":false},{"id":703565,"name":"Thomas Hart","orcid":"0000-0001-5949-9932","position":2,"is_corresponding":false},{"id":41685,"name":"Robert Homer","orcid":"0000-0002-2055-5885","position":3,"is_corresponding":false},{"id":585752,"name":"Alexia A. Belperron","orcid":"0000-0002-1734-8025","position":4,"is_corresponding":false},{"id":310994,"name":"Linda K. Bockenstedt","orcid":"0000-0001-9349-8757","position":5,"is_corresponding":false},{"id":17340,"name":"Aaron M. Ring","orcid":"0000-0003-3699-2446","position":6,"is_corresponding":false},{"id":1452879,"name":"Akira Nakamura","orcid":"0000-0003-3798-7964","position":7,"is_corresponding":false},{"id":245049,"name":"Erol Fikrig","orcid":"0000-0002-5884-6047","position":8,"is_corresponding":false},{"id":595824,"name":"Qian Yu","orcid":"0000-0002-2396-2128","position":0,"is_corresponding":true}],"reference_count":78,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T02:54:54.542303Z","pmid":"40392222","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}