{"doi":"10.7554/elife.103256.3","title":"Magnetically steered cell therapy for reduction of intraocular pressure as a treatment strategy for open-angle glaucoma","abstract":"Trabecular meshwork (TM) cell therapy has been proposed as a next-generation treatment for elevated intraocular pressure (IOP) in glaucoma, the most common cause of irreversible blindness. Using a magnetic cell steering technique with excellent efficiency and tissue-specific targeting, we delivered two types of cells into a mouse model of glaucoma: either human adipose-derived mesenchymal stem cells (hAMSCs) or induced pluripotent cell derivatives (iPSC-TM cells). We observed a 4.5 [3.1, 6.0] mmHg or 27% reduction in intraocular pressure (IOP) for 9 months after a single dose of only 1500 magnetically steered hAMSCs, explained by increased outflow through the conventional pathway and associated with a higher TM cellularity. iPSC-TM cells were also effective, but less so, showing only a 1.9 [0.4, 3.3] mmHg or 13% IOP reduction and increased risk of tumorigenicity. In both cases, injected cells remained detectable in the iridocorneal angle 3 weeks post-transplantation. Based on the locations of the delivered cells, the mechanism of IOP lowering is most likely paracrine signaling. We conclude that magnetically steered hAMSC cell therapy has potential for long-term treatment of ocular hypertension in glaucoma.","journal":"eLife","year":2025,"id":553451,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9576,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":834120,"name":"Jessica Chan","orcid":"0000-0001-6913-6174","position":1,"is_corresponding":false},{"id":336414,"name":"A. Thomas Read","orcid":"0000-0002-2764-6413","position":2,"is_corresponding":false},{"id":1334232,"name":"Guorong Li","orcid":"0009-0002-4047-8546","position":3,"is_corresponding":false},{"id":460769,"name":"Lin Cheng","orcid":"0000-0002-4960-8186","position":4,"is_corresponding":false},{"id":406427,"name":"Babak N. Safa","orcid":"0000-0002-1849-2870","position":5,"is_corresponding":false},{"id":678536,"name":"Seyed Mohammad Siadat","orcid":"0000-0002-5063-0305","position":6,"is_corresponding":false},{"id":1065030,"name":"Anamik Jhunjhunwala","orcid":"0000-0002-7126-4463","position":7,"is_corresponding":false},{"id":1334677,"name":"H. E. Grossniklaus","orcid":null,"position":8,"is_corresponding":false},{"id":382933,"name":"Stanislav Emelianov","orcid":"0000-0002-7098-133X","position":9,"is_corresponding":false},{"id":292183,"name":"W. Daniel Stamer","orcid":"0000-0002-2504-8997","position":10,"is_corresponding":false},{"id":460770,"name":"Markus H. Kuehn","orcid":"0000-0003-3940-198X","position":11,"is_corresponding":false},{"id":336418,"name":"C. Ross Ethier","orcid":"0000-0001-6110-3052","position":12,"is_corresponding":false},{"id":1450456,"name":"M Reza Bahranifard","orcid":null,"position":0,"is_corresponding":true}],"reference_count":62,"raw_metadata":null,"created_at":"2026-07-19T02:54:41.819682Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}