{"doi":"10.7554/elife.103256.1.sa2","title":"Reviewer #1 (Public review): Magnetically Steered Cell Therapy For Functional Restoration Of Intraocular Pressure Control In Open-Angle Glaucoma","abstract":"Trabecular meshwork (TM) cell therapy has been proposed as a next-generation treatment for elevated intraocular pressure (IOP) in glaucoma, the most common cause of irreversible blindness. Using a magnetic cell steering technique with excellent efficiency and tissue-specific targeting, we delivered two types of cells into a mouse model of glaucoma: either human adipose-derived mesenchymal stem cells (hAMSCs) or induced pluripotent cell derivatives (iPSC-TM cells). We observed a 4.5 [3.1, 6.0] mmHg or 27% reduction in intraocular pressure (IOP) for nine months after a single dose of only 1500 magnetically-steered hAMSCs, associated with restoration of function to the conventional outflow pathway, as judged by increased outflow facility and TM cellularity. iPSC-TM cells were also effective, but less so, showing only a 1.9 [0.4, 3.3] mmHg or 13% IOP reduction and increased risk of tumorigenicity. In both cases, injected cells remained detectable in the iridocorneal angle three weeks post-transplantation. Based on the locations of the delivered cells, the mechanism of IOP lowering is most likely paracrine signaling. We conclude that magnetically-steered hAMSC cell therapy has potential for long-term treatment of ocular hypertension in glaucoma.A novel magnetic cell therapy provided effective intraocular pressure control in a mouse model of glaucoma, motivating future translational studies.","journal":null,"year":2024,"id":506753,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9597,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":834120,"name":"Jessica Chan","orcid":"0000-0001-6913-6174","position":1,"is_corresponding":false},{"id":1358224,"name":"A Thomas Read","orcid":null,"position":2,"is_corresponding":false},{"id":392994,"name":"Guorong Li","orcid":"0000-0003-4457-3380","position":3,"is_corresponding":false},{"id":74360,"name":"Lin Cheng","orcid":"0000-0001-5694-7218","position":4,"is_corresponding":false},{"id":1358225,"name":"Babak N Safa","orcid":null,"position":5,"is_corresponding":false},{"id":678536,"name":"Seyed Mohammad Siadat","orcid":"0000-0002-5063-0305","position":6,"is_corresponding":false},{"id":1065030,"name":"Anamik Jhunjhunwala","orcid":"0000-0002-7126-4463","position":7,"is_corresponding":false},{"id":1358226,"name":"Hans E Grossniklaus","orcid":null,"position":8,"is_corresponding":false},{"id":1358227,"name":"Stanislav Y Emelianov","orcid":null,"position":9,"is_corresponding":false},{"id":1358228,"name":"W Daniel Stamer","orcid":null,"position":10,"is_corresponding":false},{"id":1358229,"name":"Markus H Kuehn","orcid":null,"position":11,"is_corresponding":false},{"id":1358230,"name":"C Ross Ethier","orcid":null,"position":12,"is_corresponding":false},{"id":1358223,"name":"M Reza Bahrani Fard","orcid":null,"position":0,"is_corresponding":true}],"reference_count":0,"raw_metadata":null,"created_at":"2026-07-19T02:10:54.646711Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}