{"doi":"10.7416/ai.2021.2428","title":"Unknown","abstract":null,"journal":null,"year":null,"id":623805,"datarank":0.1133896392166412,"base_score":0.6931471805599453,"endowment":0.6931471805599453,"self_citation_contribution":0.10397207708399181,"citation_network_contribution":0.00941756213264939,"self_endowment_contribution":0.10397207708399181,"citer_contribution":0.00941756213264939,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":1,"citers_with_citation_signal":1,"citers_with_endowment":1,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Characteristics of Clostridioides difficile colonization in Ilamian children.","abstract":"Background: The increasing colonization with Clostridioides difficile in paediatric hospitalized population is a well known event; however, its prevalence in Iranian children has not effectively been identified yet. Objective: The objective of this study was to determine the intestinal-carriage rates of C. difficile and molecular characterization of C. difficile in the Ilamian pediatric population from May 22, 2018, until September 22, 2018. Materials and Methods: Eighty samples were obtained from 40 children aged <5 years, at day 0 of their hospitalization (N=40 samples), to determine community-associated colonization, and then at day 5 days after hospitalization (N=40 samples), to determine healthcare associated colonization. The stool samples were examined for C. difficile, and isolated strains were evaluated for production of Clostridial toxins A/B and molecular characterizations. Results: The colonization rates of C. difficile and toxigenic C. difficile were 10% (8/80) and 3.75% (3/80), respectively. Based on the age group, the intestinal-carriage rates of C. difficile were 37.5, 50, and 12.5% in children ≤ 1, 1-3, and 3-5 years old, respectively. Our findings have revealed eight distinct ribotypes. Our findings have revealed eight distinct ribotypes of C. difficile isolates. Three out of 8 (37.5%) of C. difficile isolates were considered as community-associated colonization and belonged to ribotypes 7, 8, and 9. Conclusion. Our findings suggest the need of confirmation by further epidemiological studies in Iranian children. Given that the 37.5% of cases observed were community-associated, estimates of the incidence of C. difficile infections, that include only hospitalized children, may largely underestimate the burden of disease in children.","is_dataset_classified":null,"base_score":0.6931471805599453,"endowment":0.6931471805599453,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"33739354","pmcid":null,"openalex_id":"https://openalex.org/W3139486753","authors":[],"funders":[],"total_grants":0,"fwci":0.0619,"citation_percentile":0.36952462,"influential_citations":0,"citation_trend":[{"year":2022,"count":1}],"oa_status":"closed","license":null,"oa_locations":[{"url":"https://pubmed.ncbi.nlm.nih.gov/33739354","host_type":"repository"},{"url":"https://pubmed.ncbi.nlm.nih.gov/33739354/","host_type":""}],"fields_of_study":["Clostridium difficile and Clostridium perfringens research","Infection Control in Healthcare","Antibiotic Use and Resistance","Child","Clostridioides","Clostridioides difficile","Clostridium Infections","Humans","Iran","Ribotyping"],"mesh_terms":["Clostridioides","Child","Clostridium Infections","Humans","Iran","Clostridioides difficile","Ribotyping"],"keywords":["Colonization","Clostridioides","Carriage","Incidence (geometry)","Population","Epidemiology","Medicine","Microbiology","Internal medicine","Biology","Environmental health","Pathology","Children","Bacterial Colonization","Clostridioides Difficile"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-04T01:26:48.962273Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}