{"doi":"10.7326/m23-1309","title":"Blood Pressure Effect of Traffic-Related Air Pollution","abstract":"BACKGROUND: Ambient air pollution, including traffic-related air pollution (TRAP), increases cardiovascular disease risk, possibly through vascular alterations. Limited information exists about in-vehicle TRAP exposure and vascular changes. OBJECTIVE: To determine via particle filtration the effect of on-roadway TRAP exposure on blood pressure and retinal vasculature. DESIGN: Randomized crossover trial. (ClinicalTrials.gov: NCT05454930). SETTING: In-vehicle scripted commutes driven through traffic in Seattle, Washington, during 2014 to 2016. PARTICIPANTS: = 16). INTERVENTION: On 2 days, on-road air was entrained into the vehicle. On another day, the vehicle was equipped with high-efficiency particulate air (HEPA) filtration. Participants were blinded to the exposure and were randomly assigned to the sequence. MEASUREMENTS: Fourteen 3-minute periods of blood pressure were recorded before, during, and up to 24 hours after a drive. Image-based central retinal arteriolar equivalents (CRAEs) were measured before and after. Brachial artery diameter and gene expression were also measured and will be reported separately. RESULTS: = 13), at 1 hour, mean diastolic blood pressure, adjusted for predrive levels, order, and carryover, was 4.7 mm Hg higher (95% CI, 0.9 to 8.4 mm Hg) for unfiltered drives compared with filtered drives, and mean adjusted systolic blood pressure was 4.5 mm Hg higher (CI, -1.2 to 10.2 mm Hg). At 24 hours, adjusted mean diastolic blood pressure (unfiltered) was 3.8 mm Hg higher (CI, 0.02 to 7.5 mm Hg) and adjusted mean systolic blood pressure was 1.1 mm Hg higher (CI, -4.6 to 6.8 mm Hg). Adjusted mean CRAE (unfiltered) was 2.7 μm wider (CI, -1.5 to 6.8 μm). LIMITATIONS: Imprecise estimates due to small sample size; seasonal imbalance by exposure order. CONCLUSION: Filtration of TRAP may mitigate its adverse effects on blood pressure rapidly and at 24 hours. Validation is required in larger samples and different settings. PRIMARY FUNDING SOURCE: U.S. Environmental Protection Agency and National Institutes of Health.","journal":"Annals of Internal Medicine","year":2023,"id":347117,"datarank":0.5758926478200735,"base_score":2.5649493574615367,"endowment":2.5649493574615367,"self_citation_contribution":0.38474240361923057,"citation_network_contribution":0.191150244200843,"self_endowment_contribution":0.38474240361923057,"citer_contribution":0.191150244200843,"corpus_percentile":null,"corpus_rank":null,"citation_count":12,"citer_count":12,"citers_with_citation_signal":8,"citers_with_endowment":8,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9611,"is_data_producer":true,"deposit_databanks":{"ClinicalTrials.gov":["NCT05454930"]},"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":499630,"name":"Karen Jansen","orcid":"0000-0003-3494-8070","position":1,"is_corresponding":false},{"id":1089041,"name":"Kristen Cosselman","orcid":null,"position":2,"is_corresponding":false},{"id":636953,"name":"Timothy Gould","orcid":"0000-0002-0661-9133","position":3,"is_corresponding":false},{"id":1088563,"name":"James A. Stewart","orcid":"0000-0001-6024-6297","position":4,"is_corresponding":false},{"id":634491,"name":"Timothy V. Larson","orcid":"0000-0003-2208-982X","position":5,"is_corresponding":false},{"id":499629,"name":"Coralynn Sack","orcid":"0000-0003-1825-6066","position":6,"is_corresponding":false},{"id":1067840,"name":"Sverre Vedal","orcid":"0000-0002-1309-3627","position":7,"is_corresponding":false},{"id":25023,"name":"Adam A. Szpiro","orcid":"0000-0003-4995-238X","position":8,"is_corresponding":false},{"id":266060,"name":"Joel D. Kaufman","orcid":"0000-0003-4174-9037","position":9,"is_corresponding":false},{"id":634490,"name":"Michael T. Young","orcid":"0000-0002-8566-6308","position":0,"is_corresponding":true}],"reference_count":22,"raw_metadata":null,"created_at":"2026-07-19T01:11:57.720122Z","pmid":"38011704","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}