{"doi":"10.7326/aimcc.2022.0409","title":"Chronic Lymphocytic Leukemia Involving the Liver Without High-Grade Transformation","abstract":"Chronic lymphocytic leukemia is most frequently encountered among the elderly population. Hepatic infiltration may be present at the time of diagnosis, but significant extranodal involvement rarely occurs without high-grade transformation. Abnormal liver enzymes have important prognostic implications in terms of staging the disease and initiating treatment. We describe an atypical presentation of chronic lymphocytic leukemia in a patient who presented with rising liver enzyme levels, extensive hepatic infiltration, and portal hypertension but with no evidence of high-grade transformation on liver biopsy.","journal":"Annals of Internal Medicine Clinical Cases","year":2022,"id":290378,"datarank":0.29263420785754074,"base_score":1.6094379124341003,"endowment":1.6094379124341003,"self_citation_contribution":0.24141568686511508,"citation_network_contribution":0.05121852099242568,"self_endowment_contribution":0.24141568686511508,"citer_contribution":0.05121852099242568,"corpus_percentile":null,"corpus_rank":null,"citation_count":4,"citer_count":3,"citers_with_citation_signal":2,"citers_with_endowment":2,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9458,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":972773,"name":"William D. Davis","orcid":"0000-0002-4059-4590","position":1,"is_corresponding":false},{"id":350725,"name":"Megan E. Murphy","orcid":"0000-0001-5812-1356","position":2,"is_corresponding":false},{"id":973304,"name":"Melinda G. Fang","orcid":null,"position":3,"is_corresponding":false},{"id":583251,"name":"Annie J. Kruger","orcid":"0000-0001-8227-5996","position":4,"is_corresponding":false},{"id":320528,"name":"James H. Lewis","orcid":"0000-0002-6686-3744","position":5,"is_corresponding":false},{"id":972772,"name":"Alexandra V. Kimchy","orcid":"0000-0001-7345-6664","position":0,"is_corresponding":true}],"reference_count":8,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T00:30:30.639224Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}