{"doi":"10.7314/apjcp.2016.17.4.1801","title":"Circulating Cell-free miRNA Expression and its Association with Clinicopathologic Features in Inflammatory and Non-Inflammatory Breast Cancer","abstract":null,"journal":"Asian Pacific Journal of Cancer Prevention","year":2016,"id":630762,"datarank":0.37273599746820013,"base_score":2.4849066497880004,"endowment":2.4849066497880004,"self_citation_contribution":0.37273599746820013,"citation_network_contribution":0.0,"self_endowment_contribution":0.37273599746820013,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":11,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1634273,"name":"J Blancato","orcid":null,"position":1,"is_corresponding":false},{"id":1634275,"name":"D Goerlitz","orcid":null,"position":2,"is_corresponding":false},{"id":1634278,"name":"MD Islam","orcid":null,"position":3,"is_corresponding":false},{"id":1634280,"name":"B Neili","orcid":null,"position":4,"is_corresponding":false},{"id":1634282,"name":"A Abidi","orcid":null,"position":5,"is_corresponding":false},{"id":1634285,"name":"A Gat","orcid":null,"position":6,"is_corresponding":false},{"id":1634287,"name":"F Ben Ayed","orcid":null,"position":7,"is_corresponding":false},{"id":1634290,"name":"S Chivi","orcid":null,"position":8,"is_corresponding":false},{"id":1634293,"name":"CA Loffredo","orcid":null,"position":9,"is_corresponding":false},{"id":1634295,"name":"I Jillson","orcid":null,"position":10,"is_corresponding":false},{"id":1634296,"name":"A Benammar Elgaaied","orcid":null,"position":11,"is_corresponding":false},{"id":1634297,"name":"R Marrakchi","orcid":null,"position":12,"is_corresponding":false},{"id":1634272,"name":"K Hamdi","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Circulating Cell-free miRNA Expression and its Association with Clinicopathologic Features in Inflammatory and Non-Inflammatory Breast Cancer","abstract":"Recent discovery showing the presence of microRNAs (miRNAs) in the circulation sparked interest in their use as potential biomarkers. Our previous studies showed the diagnostic potential of miR-451 as a serological marker for inflammatory breast cancer (IBC), miR-337- 5p and miR-30b for non-inflammatory breast cancer (non-IBC). The aim of this study is to investigate the prognostic values of circulating miRNAs by comparing the amounts of 12 circulating miRNAs in the serum of IBC and non-IBC from Tunisian breast cancer patients, and by determinating whether correlated pairs of miRNAs could provide useful information in the diagnosis of IBC and non-IBC patients. TaqMan qPCR was performed to detect circulating expression of miRNAs in serum of 20 IBC, 20 non-IBC and 20 healthy controls. Nonparametric rank Spearman rho correlation coefficient was used to examine the prognostic value of miRNAs and to assess the correlation profile between miRNAs expression. Further, a large number of miRNAs were highly correlated (rho>0.5) in both patients groups and controls. Also, the correlations profiles were different between IBC, non-IBC and healthy controls indicating important changes in molecular pathways in cancer cells. Our results showed that miR-335 was significantly overexpressed in premenopausal non-IBC patients; miR-24 was significantly overexpressed in non-IBC postmenopausal patients. Patients with previous parity had higher serum of miR-342-5p levels than those without. Furthermore, patients with HER2+ IBC present lower serum levels of miR-15a than patients with HER2- disease. Together, these results underline the potential of miRNAs to function as diagnostic and prognostic markers for IBC and non-IBC, with links to the menopausal state, Her2 status and parity.","is_dataset_classified":null,"base_score":2.4849066497880004,"endowment":2.4849066497880004,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"27221856","pmcid":null,"openalex_id":"https://openalex.org/W2472027404","authors":[],"funders":[],"total_grants":0,"fwci":0.4719,"citation_percentile":0.64201998,"influential_citations":0,"citation_trend":[{"year":2018,"count":1},{"year":2019,"count":3},{"year":2020,"count":2},{"year":2021,"count":2},{"year":2022,"count":1},{"year":2023,"count":1},{"year":2024,"count":1}],"oa_status":"gold","license":"cc-by","oa_locations":[{"url":"http://koreascience.or.kr:80/article/JAKO201621650893728.pdf","host_type":"journal"},{"url":"http://koreascience.or.kr:80/article/JAKO201621650893728.pdf","host_type":"publisher"},{"url":"http://ocean.kisti.re.kr/downfile/crosscheck/apocp/JAKO201621650893728.pdf","host_type":"publisher"},{"url":"https://doi.org/10.7314/apjcp.2016.17.4.1801","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/27221856","host_type":"repository"}],"fields_of_study":["MicroRNA in disease regulation","Circular RNAs in diseases","Cancer-related molecular mechanisms research"],"mesh_terms":["Adult","Aged","Female","Follow-Up Studies","Humans","Middle Aged","Neoplasm Staging","Prognosis","Biomarkers, Tumor","Gene Expression Regulation, Neoplastic","Case-Control Studies","Statistics, Nonparametric","MicroRNAs","Inflammatory Breast Neoplasms","Neoplasm Grading","Real-Time Polymerase Chain Reaction"],"keywords":["Inflammatory breast cancer","microRNA","Breast cancer","Medicine","Cancer","Internal medicine","Oncology","miR-155","TaqMan","Rank correlation","Immunology","Real-time polymerase chain reaction","Biology","Gene"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-05T22:06:44.873705Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}