{"doi":"10.7150/thno.95997","title":"Millisecond-level transient heating and temperature monitoring technique for ultrasound-induced thermal strain imaging","abstract":"Background: Ultrasound-induced thermal strain imaging (US-TSI) is a promising ultrasound imaging modality that has been demonstrated in preclinical studies to identify a lipid-rich necrotic core of an atherosclerotic plaque.However, human physiological motion, e.g., cardiac pulsation, poses challenges in implementing US-TSI applications, where achieving a millisecond-level temperature rise by delivering acoustic energy from a compact US-TSI probe is a key requirement.This study aims to develop a transient ultrasound heating and thermocouple monitoring technique at the millisecond level for US-TSI applications.Methods: We designed, prototyped, and characterized a novel US-TSI probe that includes a high-power, 3.5 MHz heating transducer with symmetrical dual 1D concave array.Additionally, millisecond-level temperature monitoring was demonstrated with fast-response thermocouples in laser-and ultrasound-induced thermal tests.Subsequently, we demonstrated the prototyped US-TSI probe can produce a desired temperature rise in a millisecond-short time window in vitro phantom and in vivo animal tests.Results: The prototyped US-TSI probe delivered zero-to-peak acoustic pressure up to 6.2 MPa with a 90 VPP input voltage.Both laser-and ultrasound-induced thermal tests verified that the selected thermocouples can monitor temperature change within 50 ms.The fast-response thermocouple confirmed the transient heating ability of the US-TSI probe, achieving a 3.9 C temperature rise after a 25 ms heating duration (50% duty cycle) in the gel phantom and a 2.0 C temperature rise after a 50 ms heating duration (50% duty cycle) in a pig model. Conclusions:We successfully demonstrated a millisecond-level transient heating and temperature monitoring technique utilizing the novel US-TSI probe and fast-response thermocouples.The reported transient ultrasound heating and thermocouple monitoring technique is promising for future in vivo human subject studies in US-TSI or other ultrasound-related thermal investigations.","journal":"Theranostics","year":2024,"id":448170,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":6,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9579,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":818312,"name":"Zhiyu Sheng","orcid":"0000-0002-4209-5939","position":1,"is_corresponding":false},{"id":1106062,"name":"Ran Wei","orcid":"0000-0003-0586-5233","position":2,"is_corresponding":false},{"id":502784,"name":"Bohua Zhang","orcid":"0000-0002-9329-0507","position":3,"is_corresponding":false},{"id":502783,"name":"Howuk Kim","orcid":"0000-0002-4878-0486","position":4,"is_corresponding":false},{"id":502782,"name":"Huaiyu Wu","orcid":"0000-0003-2616-1171","position":5,"is_corresponding":false},{"id":1266815,"name":"Yu Chu","orcid":"0000-0003-0930-4628","position":6,"is_corresponding":false},{"id":274445,"name":"Qiyang Chen","orcid":"0000-0002-9509-6740","position":7,"is_corresponding":false},{"id":1267224,"name":"A. B. Breon","orcid":null,"position":8,"is_corresponding":false},{"id":420560,"name":"Sibo Li","orcid":"0000-0003-3742-4694","position":9,"is_corresponding":false},{"id":1267225,"name":"Matthew B. Wielgat","orcid":null,"position":10,"is_corresponding":false},{"id":256614,"name":"Dhanansayan Shanmuganayagam","orcid":"0000-0002-8882-1668","position":11,"is_corresponding":false},{"id":799299,"name":"Edith Tzeng","orcid":"0000-0002-5762-6798","position":12,"is_corresponding":false},{"id":599212,"name":"Xuecang Geng","orcid":null,"position":13,"is_corresponding":false},{"id":274449,"name":"Kang Kim","orcid":"0000-0003-1966-1135","position":14,"is_corresponding":false},{"id":325196,"name":"Xiaoning Jiang","orcid":"0000-0003-3605-3801","position":15,"is_corresponding":false},{"id":702201,"name":"Mengyue Chen","orcid":"0000-0002-6482-5381","position":0,"is_corresponding":true}],"reference_count":69,"raw_metadata":null,"created_at":"2026-07-19T02:02:08.018689Z","pmid":"39776794","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}