{"doi":"10.7150/thno.75966","title":"Intravital molecular imaging reveals that ROS-caspase-3-GSDME-induced cell punching enhances humoral immunotherapy targeting intracellular tumor antigens","abstract":"Tumor antigens (TAs)-induced humoral immune responses or TAs-specific antibodies have great application prospects for tumor therapy. However, more than half of TAs are intracellular antigens (intra-Ags) that are hardly recognized by antibodies. It is worthy to develop immunotherapeutic strategies for targeting intra-Ags. Methods: We used the far-red fluorescent protein tfRFP as an intracellular antigen to immunize mice and generated a liver metastasis model by injecting tfRFP-expressing B16 melanoma cells (tfRFP-B16) via the spleen. Intravital molecular imaging and atomic force microscopy were performed to visualize the formation of tfRFP antigen-antibody complexes (also known as immune complexes) and punched holes in cell membranes.","journal":"Theranostics","year":2022,"id":258143,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":18,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9641,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":909201,"name":"Ren Zhang","orcid":"0000-0001-9039-5146","position":1,"is_corresponding":false},{"id":457225,"name":"Shuhong Qi","orcid":"0000-0002-4050-6829","position":2,"is_corresponding":false},{"id":909202,"name":"Lei Liu","orcid":"0000-0002-8315-742X","position":3,"is_corresponding":false},{"id":240584,"name":"Xian Zhang","orcid":"0000-0001-9674-7886","position":4,"is_corresponding":false},{"id":909770,"name":"Deqiang Deng","orcid":null,"position":5,"is_corresponding":false},{"id":60424,"name":"Jie Zhang","orcid":"0000-0003-1587-503X","position":6,"is_corresponding":false},{"id":909203,"name":"Yilun Xu","orcid":"0009-0001-5087-9370","position":7,"is_corresponding":false},{"id":909771,"name":"Fanxuan Liu","orcid":null,"position":8,"is_corresponding":false},{"id":245750,"name":"Zheng Liu","orcid":"0000-0001-6952-3406","position":9,"is_corresponding":false},{"id":553084,"name":"Qingming Luo","orcid":null,"position":10,"is_corresponding":false},{"id":87046,"name":"Zhihong Zhang","orcid":"0000-0001-5935-1567","position":11,"is_corresponding":false},{"id":909200,"name":"Bolei Dai","orcid":"0000-0002-0158-1164","position":0,"is_corresponding":true}],"reference_count":68,"raw_metadata":null,"created_at":"2026-07-19T00:25:38.634785Z","pmid":"36438480","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}