{"doi":"10.7150/thno.51471","title":"COVID-19 and Cancer Comorbidity: Therapeutic Opportunities and Challenges","abstract":"The coronavirus disease 2019 (COVID-19) is a viral disease caused by a novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that affects the respiratory system of infected individuals. COVID-19 spreads between humans through respiratory droplets produced when an infected person coughs or sneezes. The COVID-19 outbreak originated in Wuhan, China at the end of 2019. As of 29 Sept 2020, over 235 countries, areas or territories across the globe reported a total of 33,441,919 confirmed cases, and 1,003,497 confirmed deaths due to COVID-19. Individuals of all ages are at risk for infection, but in most cases disease severity is associated with age and pre-existing diseases that compromise immunity, like cancer. Numerous reports suggest that people with cancer can be at higher risk of severe illness and related deaths from COVID-19. Therefore, managing cancer care under this pandemic is challenging and requires a collaborative multidisciplinary approach for optimal care of cancer patients in hospital settings. In this comprehensive review, we discuss the impact of the COVID-19 pandemic on cancer patients, their care, and treatment. Further, this review covers the SARS-CoV-2 pandemic, genome characterization, COVID-19 pathophysiology, and associated signaling pathways in cancer, and the choice of anticancer agents as repurposed drugs for treating COVID-19.","journal":"Theranostics","year":2020,"id":52697,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":129,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9449,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":77955,"name":"Philip Prathipati","orcid":"0000-0002-7889-779X","position":1,"is_corresponding":false},{"id":269291,"name":"Bakrudeen AA. Abdul","orcid":null,"position":2,"is_corresponding":false},{"id":269292,"name":"Srinivas Chava","orcid":null,"position":3,"is_corresponding":false},{"id":267279,"name":"Santharam S. Katta","orcid":"0000-0003-2579-8904","position":4,"is_corresponding":false},{"id":269293,"name":"Subash Gupta","orcid":null,"position":5,"is_corresponding":false},{"id":267280,"name":"Pandu R. Gangula","orcid":"0000-0001-7259-570X","position":6,"is_corresponding":false},{"id":267281,"name":"Manoj K. Pandey","orcid":"0000-0002-2767-2929","position":7,"is_corresponding":false},{"id":267282,"name":"Donald L. Durden","orcid":"0000-0001-5386-1427","position":8,"is_corresponding":false},{"id":69434,"name":"Siddappa N. Byrareddy","orcid":"0000-0002-6889-4640","position":9,"is_corresponding":false},{"id":267283,"name":"Kishore B. Challagundla","orcid":"0000-0001-8654-7717","position":10,"is_corresponding":false},{"id":267278,"name":"Anup S. Pathania","orcid":"0000-0002-1517-2919","position":0,"is_corresponding":true}],"reference_count":238,"raw_metadata":null,"created_at":"2026-07-18T20:43:25.742124Z","pmid":"33391502","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}