{"doi":"10.7150/thno.100116","title":"Collagen type I PET/MRI enables evaluation of treatment response in pancreatic cancer in pre-clinical and first-in-human translational studies","abstract":"Pancreatic ductal adenocarcinoma (PDAC) is an invasive and rapidly progressive malignancy.A major challenge in patient management is the lack of a reliable imaging tool to monitor tumor response to treatment.Tumor-associated fibrosis characterized by high type I collagen is a hallmark of PDAC, and fibrosis further increases in response to neoadjuvant chemoradiotherapy (CRT).We hypothesized that molecular positron emission tomography (PET) using a type I collagen-specific imaging probe, 68 Ga-CBP8 can detect and measure changes in tumor fibrosis in response to standard treatment in mouse models and patients with PDAC.Methods: We evaluated the specificity of 68 Ga-CBP8 PET to tumor collagen and its ability to differentiate responders from non-responders based on the dynamic changes of fibrosis in nude mouse models of human PDAC including FOLFIRNOX-sensitive (PANC-1 and PDAC6) and .Next, we demonstrated the specificity and sensitivity of 68 Ga-CBP8 to the deposited collagen in resected human PDAC and pancreas tissues.Eight male participant (49-65 y) with newly diagnosed PDAC underwent dynamic 68 Ga-CBP8 PET/MRI, and five underwent follow up 68 Ga-CBP8 PET/MRI after completing standard CRT.PET parameters were correlated with tumor collagen content and markers of response on histology.Results: 68 Ga-CBP8 showed specific binding to PDAC compared to non-binding 68 Ga-CNBP probe in two mouse models of PDAC using PET imaging and to resected human PDAC using autoradiography (P < 0.05 for all comparisons).68 Ga-CBP8 PET showed 2-fold higher tumor signal in mouse models following FOLFIRINOX treatment in PANC-1 and PDAC6 models (P < 0.01), but no significant increase after treatment in FOLFIRINOX resistant SU.86.86 model.68 Ga-CBP8 binding to resected human PDAC was significantly higher (P < 0.0001) in treated versus untreated tissue.PET/MRI of PDAC patients prior to Ivyspring International","journal":"Theranostics","year":2024,"id":426165,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":18,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9584,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1065025,"name":"Hua Ma","orcid":"0000-0002-7966-6862","position":1,"is_corresponding":false},{"id":965900,"name":"Shriya Krishna","orcid":"0009-0004-2402-0484","position":2,"is_corresponding":false},{"id":516645,"name":"Sergey Shuvaev","orcid":"0000-0001-7903-0648","position":3,"is_corresponding":false},{"id":1225014,"name":"Mark F Sabbagh","orcid":"0000-0003-1996-5251","position":4,"is_corresponding":false},{"id":1225579,"name":"Caitlin Deffler","orcid":null,"position":5,"is_corresponding":false},{"id":345135,"name":"Nicholas J. 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